Oligodendroglia heterogeneity in the human central nervous system.
Heterogeneity
Myelin
Oligodendrocytes
Oligodendroglia
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
27
08
2021
accepted:
28
11
2021
revised:
30
10
2021
pubmed:
4
12
2021
medline:
8
3
2022
entrez:
3
12
2021
Statut:
ppublish
Résumé
It is the centenary of the discovery of oligodendrocytes and we are increasingly aware of their importance in the functioning of the brain in development, adult learning, normal ageing and in disease across the life course, even in those diseases classically thought of as neuronal. This has sparked more interest in oligodendroglia for potential therapeutics for many neurodegenerative/neurodevelopmental diseases due to their more tractable nature as a renewable cell in the central nervous system. However, oligodendroglia are not all the same. Even from the first description, differences in morphology were described between the cells. With advancing techniques to describe these differences in human tissue, the complexity of oligodendroglia is being discovered, indicating apparent functional differences which may be of critical importance in determining vulnerability and response to disease, and targeting of potential therapeutics. It is timely to review the progress we have made in discovering and understanding oligodendroglial heterogeneity in health and neuropathology.
Identifiants
pubmed: 34860266
doi: 10.1007/s00401-021-02390-4
pii: 10.1007/s00401-021-02390-4
pmc: PMC8742806
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-157Subventions
Organisme : Medical Research Council
ID : MR/P016022/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035915/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T015594/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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