Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M

Chromatography, Liquid DNA-Directed DNA Polymerase / metabolism Deoxyguanosine / analogs & derivatives Humans Molecular Structure Oligonucleotides / chemical synthesis Tandem Mass Spectrometry DNA Polymerase iota

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
20 12 2021
Historique:
pubmed: 4 12 2021
medline: 19 1 2022
entrez: 3 12 2021
Statut: ppublish

Résumé

The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M

Identifiants

DOI: 10.1021/acs.chemrestox.1c00334 PMID: 34860508 PMC: PMC10518890
pubmed: 34860508
doi: 10.1021/acs.chemrestox.1c00334
pmc: PMC10518890
mid: NIHMS1923192
doi:

Substances chimiques

Oligonucleotides 0
DNA-Directed DNA Polymerase EC 2.7.7.7
Deoxyguanosine G9481N71RO
DNA Polymerase iota EC 2.7.7.7
POLI protein, human EC 2.7.7.7

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2567-2578

Subventions

Organisme : NCI NIH HHS
ID : R01 CA087819
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA087819
Pays : United States

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Auteurs

Plamen P Christov (PP)

Department of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Robyn Richie-Jannetta (R)

A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Philip J Kingsley (PJ)

A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Anoop Vemulapalli (A)

A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Kwangho Kim (K)

Department of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Gary A Sulikowski (GA)

Department of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
ORCID: 0000-0002-1067-0767

Carmelo J Rizzo (CJ)

Departments of Chemistry and Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.

Amit Ketkar (A)

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.

Robert L Eoff (RL)

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
ORCID: 0000-0003-4776-8925

Carol A Rouzer (CA)

A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
ORCID: 0000-0001-6827-1534

Lawrence J Marnett (LJ)

A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
ORCID: 0000-0002-7834-6285

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléoside purique › Désoxyguanosine › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Site-Specific Synthesis of Oligonucleotides...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › ADN Polymérase iota › Site-Specific Synthesis of Oligonucleotides...