Viral proteases: Structure, mechanism and inhibition.
Coronavirus
Drug resistance
Enterovirus
Flavivirus
HCV
HIV-1
HTLV-1
Protease inhibitors
Substrate envelope
Viral protease
Journal
The Enzymes
ISSN: 0423-2607
Titre abrégé: Enzymes
Pays: United States
ID NLM: 101637215
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
4
12
2021
pubmed:
5
12
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV), human T-cell leukemia virus type 1 (HTLV-1), flaviviruses, enteroviruses, and coronaviruses. The proteases of HIV-1 and HCV have been successfully targeted for therapeutics, with picomolar FDA-approved drugs currently used in the clinic. The proteases of HTLV-1 and the other virus families remain emerging therapeutic targets at different stages of the drug development process. This chapter provides an overview of the current knowledge on viral protease structure, mechanism, substrate recognition, and inhibition. Particular focus is placed on recent advances in understanding the molecular basis of diverse substrate recognition and resistance, which is essential toward designing novel protease inhibitors as antivirals.
Identifiants
pubmed: 34861941
pii: S1874-6047(21)00021-4
doi: 10.1016/bs.enz.2021.09.004
pmc: PMC8595904
pii:
doi:
Substances chimiques
Antiviral Agents
0
Protease Inhibitors
0
Viral Proteases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-333Subventions
Organisme : NIGMS NIH HHS
ID : F31 GM131635
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085051
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135919
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149716
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Bioorg Med Chem Lett. 2020 Mar 1;30(5):126965
pubmed: 31980339
Biochemistry. 2004 Apr 20;43(15):4568-74
pubmed: 15078103
Curr Pharm Des. 2014;20(21):3422-7
pubmed: 24001226
PLoS Pathog. 2017 May 25;13(5):e1006411
pubmed: 28542603
J Chem Theory Comput. 2017 Nov 14;13(11):5671-5682
pubmed: 28915040
Antimicrob Agents Chemother. 2003 Dec;47(12):3907-16
pubmed: 14638501
J Chem Theory Comput. 2014 Aug 12;10(8):3438-3448
pubmed: 25136270
Virol J. 2015 Feb 08;12:16
pubmed: 25886260
Lancet. 2020 Feb 15;395(10223):470-473
pubmed: 31986257
Cell Res. 2017 Aug;27(8):1046-1064
pubmed: 28685770
Antiviral Res. 2017 Mar;139:49-58
pubmed: 28034741
J Med Chem. 2016 Jun 23;59(12):5622-49
pubmed: 26771861
Chem Rev. 2002 Dec;102(12):4501-24
pubmed: 12475199
Antiviral Res. 2017 Jul;143:218-229
pubmed: 28461069
Adv Virus Res. 2003;59:23-61
pubmed: 14696326
Structure. 2018 Apr 3;26(4):555-564.e3
pubmed: 29526431
J Med Chem. 2019 Sep 12;62(17):8062-8079
pubmed: 31386368
Ann Intern Med. 1989 Dec 1;111(11):871-5
pubmed: 2573306
Chem Rev. 2021 Mar 24;121(6):3238-3270
pubmed: 33410674
J Med Chem. 2020 Nov 12;63(21):12725-12747
pubmed: 33054210
ACS Infect Dis. 2019 Feb 8;5(2):316-325
pubmed: 30543749
J Med Virol. 2020 May;92(5):522-528
pubmed: 32027036
ACS Infect Dis. 2016 Oct 14;2(10):734-743
pubmed: 27657335
J Mol Biol. 2009 Feb 6;385(5):1568-77
pubmed: 19059417
Cell Host Microbe. 2016 May 11;19(5):561-5
pubmed: 27091703
Nat Commun. 2021 Oct 18;12(1):6055
pubmed: 34663813
J Virol. 2008 May;82(9):4227-34
pubmed: 18305043
Org Biomol Chem. 2003 Jan 7;1(1):5-14
pubmed: 12929379
ACS Chem Biol. 2021 Mar 19;16(3):529-538
pubmed: 33619959
J Virol. 1993 May;67(5):2832-43
pubmed: 8386278
Nature. 2013 Apr 25;496(7446):504-7
pubmed: 23563266
Structure. 2002 Mar;10(3):369-81
pubmed: 12005435
J Virol. 1993 Jul;67(7):3835-44
pubmed: 8389908
Arch Virol. 2020 Jul;165(7):1517-1526
pubmed: 32322993
ACS Med Chem Lett. 2018 May 17;9(7):691-696
pubmed: 30034602
Chem Biol. 2013 Sep 19;20(9):1116-24
pubmed: 24012370
Curr Opin Microbiol. 2004 Aug;7(4):412-9
pubmed: 15358261
Bioorg Med Chem. 2008 Jul 15;16(14):6880-90
pubmed: 18558491
ACS Omega. 2018 Dec 31;3(12):18132-18141
pubmed: 30613818
Structure. 2018 Oct 2;26(10):1360-1372.e5
pubmed: 30146168
J Virol. 1993 Mar;67(3):1385-95
pubmed: 7679746
J Virol. 2008 Jan;82(1):173-83
pubmed: 17942558
J Mol Biol. 2011 Jul 22;410(4):726-44
pubmed: 21762811
Trends Microbiol. 2017 Oct;25(10):797-808
pubmed: 28789826
Antiviral Res. 2018 Dec;160:17-24
pubmed: 30315877
Biochemistry. 2019 Sep 3;58(35):3711-3726
pubmed: 31386353
Chem Biol. 2003 May;10(5):373-80
pubmed: 12770819
ACS Omega. 2020 Sep 29;5(40):25677-25686
pubmed: 33073093
J Virol. 1995 May;69(5):2863-8
pubmed: 7707509
Annu Rev Microbiol. 2008;62:71-92
pubmed: 18429680
Crit Rev Biochem Mol Biol. 2019 Feb;54(1):11-26
pubmed: 30821513
Chem Rev. 2014 Nov 26;114(22):11348-81
pubmed: 25268322
J Virol. 2013 Apr;87(8):4339-51
pubmed: 23388726
mBio. 2020 Mar 31;11(2):
pubmed: 32234812
N Engl J Med. 2018 Jan 25;378(4):354-369
pubmed: 29365309
Lancet. 2015 Apr 25;385(9978):1662-71
pubmed: 25638662
PLoS Negl Trop Dis. 2016 Mar 18;10(3):e0004589
pubmed: 26991663
Antimicrob Agents Chemother. 2005 Jun;49(6):2267-75
pubmed: 15917520
J Virol. 2011 Oct;85(20):10764-73
pubmed: 21835784
J Am Chem Soc. 2016 Sep 14;138(36):11850-9
pubmed: 27512818
Viruses. 2010 Nov;2(11):2509-2535
pubmed: 21994628
Biochem Biophys Res Commun. 1993 Apr 30;192(2):399-406
pubmed: 8387277
Nat Struct Mol Biol. 2006 Apr;13(4):372-3
pubmed: 16532006
Viruses. 2018 Dec 17;10(12):
pubmed: 30562987
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12997-13002
pubmed: 27799534
Curr Pharm Des. 2007;13(12):1285-94
pubmed: 17504236
ACS Chem Biol. 2013 Jul 19;8(7):1469-78
pubmed: 23594083
Bioorg Med Chem Lett. 2006 Jan 1;16(1):40-3
pubmed: 16246563
J Biomol NMR. 2019 Jul;73(6-7):365-374
pubmed: 31243634
J Am Chem Soc. 2014 Aug 27;136(34):11956-63
pubmed: 25091085
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18332-7
pubmed: 16352712
J Chem Theory Comput. 2013 Dec 10;9(12):5693-5705
pubmed: 24587770
J Virol. 2010 May;84(10):5368-78
pubmed: 20237088
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10773-7
pubmed: 7504283
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Methods Mol Biol. 2012;819:551-60
pubmed: 22183557
J Virol. 2012 Jan;86(1):438-46
pubmed: 22031935
Antimicrob Agents Chemother. 2015 Nov 23;60(2):913-24
pubmed: 26596952
Protein Cell. 2011 Apr;2(4):282-90
pubmed: 21533772
ACS Chem Biol. 2016 Apr 15;11(4):900-9
pubmed: 26682473
Blood. 2006 Jan 15;107(2):716-24
pubmed: 16174765
Bioorg Med Chem Lett. 2020 Sep 1;30(17):127377
pubmed: 32738988
Org Lett. 2019 Jun 21;21(12):4709-4712
pubmed: 31188009
J Virol. 2011 Oct;85(19):10319-31
pubmed: 21795339
Chem Biol. 2004 Oct;11(10):1333-8
pubmed: 15489160
Antiviral Res. 2017 May;141:29-37
pubmed: 28185815
ACS Chem Biol. 2019 Nov 15;14(11):2441-2452
pubmed: 31361460
J Virol Methods. 2004 Aug;119(2):87-93
pubmed: 15158589
J Virol. 2011 Oct;85(19):10021-30
pubmed: 21813612
J Mol Biol. 2010 Aug 27;401(4):626-41
pubmed: 20600105
Bull World Health Organ. 2017 Jul 01;95(7):517-525I
pubmed: 28670016
Nat Commun. 2020 Nov 18;11(1):5877
pubmed: 33208735
PLoS One. 2015 Dec 14;10(12):e0144865
pubmed: 26658006
ACS Chem Biol. 2013 Dec 20;8(12):2744-52
pubmed: 24164286
PLoS Pathog. 2012;8(7):e1002832
pubmed: 22910833
J Autoimmun. 2020 May;109:102434
pubmed: 32143990
Virus Res. 1999 Aug;62(2):159-68
pubmed: 10507325
Trends Microbiol. 2016 Jul;24(7):547-557
pubmed: 27090931
J Virol. 2008 Mar;82(5):2515-27
pubmed: 18094151
Science. 2016 Dec 23;354(6319):1597-1600
pubmed: 27940580
Nat Commun. 2016 Nov 15;7:13410
pubmed: 27845325
Acta Pharm Sin B. 2016 Jan;6(1):26-31
pubmed: 26904396
Anal Biochem. 2009 Dec 15;395(2):195-204
pubmed: 19682971
ACS Chem Biol. 2014 Nov 21;9(11):2485-90
pubmed: 25243902
ACS Chem Biol. 2020 Feb 21;15(2):342-352
pubmed: 31868341
J Med Chem. 2022 Feb 24;65(4):2794-2808
pubmed: 33872498
J Med Chem. 2017 Jul 13;60(13):5699-5716
pubmed: 28594175
ACS Chem Biol. 2013 Mar 15;8(3):513-8
pubmed: 23252515
J Virol. 1993 Aug;67(8):4665-75
pubmed: 8392606
Handb Exp Pharmacol. 2009;(189):85-110
pubmed: 19048198
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20986-91
pubmed: 21084633
ACS Med Chem Lett. 2019 Jan 04;10(2):168-174
pubmed: 30783498
Lancet Infect Dis. 2016 May;16(5):e64-e75
pubmed: 26929196
Virus Res. 2008 Apr;133(1):63-73
pubmed: 17397958
Infect Drug Resist. 2018 Aug 08;11:1119-1135
pubmed: 30127629
J Chem Theory Comput. 2018 May 8;14(5):2784-2796
pubmed: 29570286
J Med Chem. 2016 Jul 28;59(14):6595-628
pubmed: 26878082
Nat Rev Microbiol. 2018 Jun;16(6):368-381
pubmed: 29626210
Bioorg Med Chem. 2021 Jan 1;29:115860
pubmed: 33191083
ACS Chem Biol. 2012 Sep 21;7(9):1536-46
pubmed: 22712830
J Med Chem. 2016 Jun 9;59(11):5172-208
pubmed: 26799988
Proteins. 2007 Aug 1;68(2):561-7
pubmed: 17474129
J Med Chem. 2020 Aug 13;63(15):8296-8313
pubmed: 32672965
Science. 2016 Jul 22;353(6297):353-4
pubmed: 27417493
J Chem Theory Comput. 2021 Apr 13;17(4):2054-2064
pubmed: 33783217
J Med Chem. 2019 Dec 26;62(24):11359-11382
pubmed: 31769670
Bioorg Med Chem Lett. 2006 Jan 1;16(1):36-9
pubmed: 16246553
J Virol. 2017 Apr 28;91(10):
pubmed: 28298600
J Med Chem. 2014 Jul 24;57(14):6266-72
pubmed: 25006983
J Chem Theory Comput. 2012 Oct 9;8(10):3452-3462
pubmed: 23144597
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10583-7
pubmed: 8248148