Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era.
falciparum malaria
hemoglobin S
malaria-attributable mortality
sickle cell
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
21
09
2021
revised:
25
10
2021
accepted:
25
10
2021
pubmed:
5
12
2021
medline:
9
4
2022
entrez:
4
12
2021
Statut:
ppublish
Résumé
Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
Identifiants
pubmed: 34862145
pii: S1471-4922(21)00262-2
doi: 10.1016/j.pt.2021.10.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-14Subventions
Organisme : Wellcome Trust
ID : 220211
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.