Amikacin in emergency surgery: How to dose it optimally?
Amikacin
Emergency surgery
Intra-abdominal infections
Pharmacokinetics
Journal
Anaesthesia, critical care & pain medicine
ISSN: 2352-5568
Titre abrégé: Anaesth Crit Care Pain Med
Pays: France
ID NLM: 101652401
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
17
05
2021
revised:
11
10
2021
accepted:
26
10
2021
pubmed:
6
12
2021
medline:
9
3
2022
entrez:
5
12
2021
Statut:
ppublish
Résumé
Amikacin is still a recommended option in emergency surgery. Current guidelines have suggested an amikacin dose of 15-20 mg/kg/24 h for intra-abdominal infections (IAI). Our objectives were to analyse amikacin pharmacokinetics (PK) and dosage requirements in patients who underwent emergency surgery, and to identify an optimal dosing approach. We performed a retrospective data analysis of patients who received amikacin for emergency surgery over 2.5 years, with measurement of both peak (C
Identifiants
pubmed: 34863966
pii: S2352-5568(21)00194-6
doi: 10.1016/j.accpm.2021.100990
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Amikacin
84319SGC3C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100990Informations de copyright
Copyright © 2021 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.