Important factors improving outcome of young adults with acute lymphoblastic leukemia (ALL).
Acute lymphoblastic leukemia
Clinical trials
Incidence peak
Pediatric treatment regimen
Psychosocial care
Young adults
Journal
Best practice & research. Clinical haematology
ISSN: 1532-1924
Titre abrégé: Best Pract Res Clin Haematol
Pays: Netherlands
ID NLM: 101120659
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
Four categories of important factors improving outcome of young adults and older adolescents with acute lymphoblastic leukemia (ALL) are biologic type, clinical trials, pediatric vs. adult treatment regimen, and psychosocial challenges. Overall, the outcome of ALL in the age group has improved and beginning to catch up with that in children, as exemplified by CALGB 10403, a pediatric treatment regimen. Each is dependent for optimum development, however, on progress in the others. Without adequate psychosocial support and improvement, progress in clinical trials, translational research, and pediatric regimen application is impaired. Without clinical trials, advances in translational research, optimal pediatric regimen application and adequate psychosocial research are restricted. Overall, we have improved the outcome and outlook of ALL in AYAs, as exemplified by CALGB 10403, but we and our current and future patients still have a long way to go.
Identifiants
pubmed: 34865694
pii: S1521-6926(21)00087-6
doi: 10.1016/j.beha.2021.101322
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101322Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.