Impact of percutaneous coronary intervention of chronic total occlusions on absolute perfusion in remote myocardium.
Journal
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
ISSN: 1969-6213
Titre abrégé: EuroIntervention
Pays: France
ID NLM: 101251040
Informations de publication
Date de publication:
22 Jul 2022
22 Jul 2022
Historique:
pubmed:
7
12
2021
medline:
26
7
2022
entrez:
6
12
2021
Statut:
epublish
Résumé
Revascularisation of a chronic total coronary occlusion (CTO) impacts the coronary physiology of the remote myocardial territory. This study aimed to evaluate the intrinsic effect of CTO percutaneous coronary intervention (PCI) on changes in absolute perfusion in remote myocardium. A total of 164 patients who underwent serial [ Perfusion indices in CTO and remote myocardium showed a positive correlation before (resting MBF: r=0.84, hMBF: r=0.75, and CFR: r=0.77, p<0.01 for all) and after (resting MBF: r=0.87, hMBF: r=0.87, and CFR: r=0.81, p<0.01 for all) CTO PCI. Absolute increases in hMBF and CFR were observed in remote myocardium following CTO revascularisation (from 2.29±0.67 to 2.48±0.75 mL·min CTO revascularisation resulted in an increase in remote myocardial perfusion. Furthermore, the quantitative improvement in hMBF and CFR in the CTO territory was independently associated with the absolute perfusion increase in remote myocardial regions. As such, CTO PCI may have a favourable physiologic impact beyond the intended treated myocardium.
Sections du résumé
BACKGROUND
BACKGROUND
Revascularisation of a chronic total coronary occlusion (CTO) impacts the coronary physiology of the remote myocardial territory.
AIMS
OBJECTIVE
This study aimed to evaluate the intrinsic effect of CTO percutaneous coronary intervention (PCI) on changes in absolute perfusion in remote myocardium.
METHODS
METHODS
A total of 164 patients who underwent serial [
RESULTS
RESULTS
Perfusion indices in CTO and remote myocardium showed a positive correlation before (resting MBF: r=0.84, hMBF: r=0.75, and CFR: r=0.77, p<0.01 for all) and after (resting MBF: r=0.87, hMBF: r=0.87, and CFR: r=0.81, p<0.01 for all) CTO PCI. Absolute increases in hMBF and CFR were observed in remote myocardium following CTO revascularisation (from 2.29±0.67 to 2.48±0.75 mL·min
CONCLUSIONS
CONCLUSIONS
CTO revascularisation resulted in an increase in remote myocardial perfusion. Furthermore, the quantitative improvement in hMBF and CFR in the CTO territory was independently associated with the absolute perfusion increase in remote myocardial regions. As such, CTO PCI may have a favourable physiologic impact beyond the intended treated myocardium.
Identifiants
pubmed: 34866043
pii: EIJ-D-21-00702
doi: 10.4244/EIJ-D-21-00702
pmc: PMC9912974
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e314-e323Références
J Interv Cardiol. 2018 Oct;31(5):562-571
pubmed: 29974508
EuroIntervention. 2020 Aug 07;16(6):e462-e471
pubmed: 31543497
Circ Cardiovasc Interv. 2015 Apr;8(4):
pubmed: 25805570
J Am Coll Cardiol. 2018 Oct 30;72(18):2231-2264
pubmed: 30153967
JACC Cardiovasc Interv. 2008 Feb;1(1):44-53
pubmed: 19393143
Cardiol J. 2022;29(1):80-87
pubmed: 32037503
Circ Cardiovasc Interv. 2018 Nov;11(11):e006941
pubmed: 30571203
Eur Heart J. 2018 Jul 7;39(26):2484-2493
pubmed: 29722796
Circulation. 2019 Jul 30;140(5):420-433
pubmed: 31356129
JACC Cardiovasc Interv. 2021 Jul 12;14(13):1407-1418
pubmed: 34238551
Heart. 2014 Jun;100(12):951-9
pubmed: 24727867
Circulation. 2002 Jan 29;105(4):539-42
pubmed: 11815441
EuroIntervention. 2017 Jun 20;13(3):345-354
pubmed: 28242588
EuroIntervention. 2020 Aug 07;16(6):e453-e461
pubmed: 32122823
Curr Cardiol Rev. 2014 Feb;10(1):57-64
pubmed: 24611646
Catheter Cardiovasc Interv. 2016 May;87(6):1071-9
pubmed: 26756537
J Am Coll Cardiol. 2006 Jul 4;48(1):51-8
pubmed: 16814648
Heart. 2004 Nov;90(11):1303-9
pubmed: 15486127
JACC Cardiovasc Interv. 2017 Mar 27;10(6):585-593
pubmed: 28335895
Circ Cardiovasc Interv. 2013 Feb;6(1):29-36
pubmed: 23322740
J Am Coll Cardiol. 2012 Mar 13;59(11):991-7
pubmed: 22402070
J Am Coll Cardiol. 1993 Sep;22(3):650-8
pubmed: 8354794
Neth Heart J. 2021 Jan;29(1):22-29
pubmed: 32720123
Catheter Cardiovasc Interv. 2018 Sep 1;92(3):E139-E148
pubmed: 29569332
Eur Heart J. 2006 Oct;27(20):2406-12
pubmed: 17003048
J Am Coll Cardiol. 2014 Oct 7;64(14):1464-75
pubmed: 25277618
Circulation. 2005 Oct 11;112(15):2364-72
pubmed: 16216980
J Am Heart Assoc. 2020 May 5;9(9):e015669
pubmed: 32316813
Circulation. 2003 Dec 9;108(23):2877-82
pubmed: 14623811
Eur J Nucl Med Mol Imaging. 2011 May;38(5):930-9
pubmed: 21271246