Body mass index and cancer mortality in patients with incident type 2 diabetes: A population-based study of adults in England.
BMI
cancer
mortality
obesity
type 2 diabetes
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
14
11
2021
received:
04
07
2021
accepted:
01
12
2021
pubmed:
7
12
2021
medline:
1
4
2022
entrez:
6
12
2021
Statut:
ppublish
Résumé
We evaluated the relationship between body mass index (BMI) and cancer mortality in incident type 2 diabetes. We used the Clinical Practice Research Datalink GOLD (1998-2015), linked with the Office of National Statistics mortalities, and derived an incident type 2 diabetes cohort (N = 176 886; aged 30-85 years). We determined BMI ±12 months diabetes diagnosis. The primary outcome was cancer mortality, categorized into deaths from obesity-related cancers (ORCs) and non-ORCs. Secondary outcomes were site-specific cancer mortality and main causes of deaths [cancer, cardiovascular disease (CVD), non-cancer non-CVD]. We developed gender-specific Cox models and expressed risk as hazard ratios and 95% confidence intervals, stratified by smoking status. With 886 850 person-years follow-up, 7593 cancer deaths occurred. Among women who never smoked, there were positive associations between BMI and deaths from endometrial (hazard ratios per 5 kg/m We found some relationships between BMI and cancer mortality in patients with type 2 diabetes, but interpretations need to account for smoking status, reverse causality and deaths from CVD.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
620-630Subventions
Organisme : Cancer Research UK Manchester Centre
ID : C147/A18083
Organisme : Cancer Research UK Manchester Centre
ID : C147/A25254
Organisme : Manchester NIHR Biomedical Research Centre
ID : IS-BRC-1215-20007
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Gregg EW, Gu Q, Cheng YJ, Narayan KM, Cowie CC. Mortality trends in men and women with diabetes, 1971 to 2000. Ann Intern Med. 2007;147(3):149-155.
Dale AC, Vatten LJ, Nilsen TI, Midthjell K, Wiseth R. Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study. BMJ (Clinical Research Ed). 2008;337:a236.
Eliasson M, Talback M, Rosen M. Improved survival in both men and women with diabetes between 1980 and 2004-a cohort study in Sweden. Cardiovasc Diabetol. 2008;7:32.
Wright AK, Kontopantelis E, Emsley R, et al. Life expectancy and cause-specific mortality in type 2 diabetes: a population-based cohort study quantifying relationships in ethnic subgroups. Diabetes Care. 2017;40(3):338-345.
Faerch K, Carstensen B, Almdal TP, Jorgensen ME. Improved survival among patients with complicated type 2 diabetes in Denmark: a prospective study (2002-2010). J Clin Endocrinol Metab. 2014;99(4):E642-E646.
Campbell PT, Newton CC, Patel AV, Jacobs EJ, Gapstur SM. Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care. 2012;35(9):1835-1844.
Rawshani A, Rawshani A, Franzen S, et al. Mortality and cardiovascular disease in type 1 and type 2 diabetes. N Engl J Med. 2017;376(15):1407-1418.
Pearson-Stuttard J, Bennett J, Cheng YJ, et al. Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records. Lancet Diabetes Endocrinol. 2021;9(3):165-173.
Ohkuma T, Peters SAE, Woodward M. Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events. Diabetologia. 2018;61(10):2140-2154.
Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer--Viewpoint of the IARC Working Group. N Engl J Med. 2016;375(8):794.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet (London, England). 2008;371(9612):569-578.
Kubota Y, Iso H, Tamakoshi A. Association of body mass index and mortality in Japanese diabetic men and women based on self-reports: the Japan Collaborative Cohort (JACC) Study. J Epidemiol. 2015;25(8):553-558.
Landman GW, Van Hateren KJ, Kleefstra N, Bilo HJ. The relationship between obesity and cancer mortality in type 2 diabetes: a ten-year follow-up study (ZODIAC-21). Anticancer Res. 2010;30(2):681-682.
Tseng CH. Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis. 2013;226(1):186-192.
Drake I, Gullberg B, Sonestedt E, et al. Type 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting. Int J Cancer. 2017;141(6):1170-1180.
Tobias DK, Pan A, Jackson CL, et al. Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med. 2014;370(3):233-244.
de Lusignan S, Khunti K, Belsey J, et al. A method of identifying and correcting miscoding, misclassification and misdiagnosis in diabetes: a pilot and validation study of routinely collected data. Diabet Med. 2010;27(2):203-209.
Madley-Dowd P, Hughes R, Tilling K, Heron J. The proportion of missing data should not be used to guide decisions on multiple imputation. J Clin Epidemiol. 2019;110:63-73.
McLennan D, Barnes H, Noble M, Dibben C. The English Indices of Deprivation 2010 for the Department for Communities and Local Government, 2011. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/6320/1870718.pdf. Accessed May 12, 2018.
Joseph RM, Movahedi M, Dixon WG, Symmons DP. Smoking-related mortality in patients with early rheumatoid arthritis: a retrospective cohort study using the clinical practice research datalink. Arthritis Care Res. 2016;68(11):1598-1606.
Hinchliffe SR, Lambert PC. Flexible parametric modelling of cause-specific hazards to estimate cumulative incidence functions. BMC Med Res Methodol. 2013;13:13.
Renehan AG. Cumulative incidence of metachronous colorectal cancer risk for mismatch repair gene mutation carriers is overestimated. Gut. 2011;61:783.
Renehan AG, Zwahlen M, Egger M. Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer. 2015;15(8):484-498.
Yang DX, Khera R, Miccio JA, et al. Prevalence of missing data in the national cancer database and association with overall survival. JAMA Netw Open. 2021;4(3):e211793.
Knol MJ, Janssen KJ, Donders AR, et al. Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical example. J Clin Epidemiol. 2010;63(7):728-736.
Badrick E, Sperrin M, Buchan IE, Renehan AG. Obesity paradox and mortality in adults with and without incident type 2 diabetes: a matched population-level cohort study. BMJ Open Diabetes Res Care. 2017;5(1):e000369.
Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308(6):581-590.
Arnold M, Jiang L, Stefanick ML, et al. Duration of adulthood overweight, obesity, and cancer risk in the women's health initiative: a longitudinal study from the United States. PLoS Med. 2016;13(8):e1002081.
Farmer RE, Ford D, Mathur R, et al. Metformin use and risk of cancer in patients with type 2 diabetes: a cohort study of primary care records using inverse probability weighting of marginal structural models. Int J Epidemiol. 2019;48(2):527-537.