Tight Junctions of the Neurovascular Unit.
blood brain barrier
endothelial cells
inner blood-retinal barrier
neurovasculature
tight junction
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
08
2021
accepted:
07
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology.
Identifiants
pubmed: 34867185
doi: 10.3389/fnmol.2021.752781
pmc: PMC8640090
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
752781Informations de copyright
Copyright © 2021 Hudson and Campbell.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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