Disease Duration Influences Gene Expression in Neuromelanin-Positive Cells From Parkinson's Disease Patients.
Parkinson’s disease
RNA sequencing
cell death
disease duration
gene expression
neurodegenerative disease
neuroprotection
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
08
2021
accepted:
19
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
Analyses of gene expression in cells affected by neurodegenerative disease can provide important insights into disease mechanisms and relevant stress response pathways. Major symptoms in Parkinson's disease (PD) are caused by the degeneration of midbrain dopamine (mDA) neurons within the substantia nigra. Here we isolated neuromelanin-positive dopamine neurons by laser capture microdissection from
Identifiants
pubmed: 34867188
doi: 10.3389/fnmol.2021.763777
pmc: PMC8632647
doi:
Types de publication
Journal Article
Langues
eng
Pagination
763777Informations de copyright
Copyright © 2021 Tiklová, Gillberg, Volakakis, Lundén-Miguel, Dahl, Serrano, Adler, Beach and Perlmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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