A New Report of Combined Central and Peripheral Demyelination: A Case Report.
GQ1b
MRI
combined central and peripheral demyelinating disease
miller-fisher syndrome
multiple sclerosis
radiologically isolated syndrome
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
06
2021
accepted:
14
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
Combined central and peripheral demyelination (CCPD) is not encountered frequently in the clinical practice, and it requires a high level of suspicion for diagnosis. We describe a case of a young man who was diagnosed with radiologically isolated syndrome (RIS) after presenting initially with symptoms suggestive of central nervous system (CNS) insult in the form of double vision, slurred speech, left-sided numbness, and unsteadiness. However, on the next day of admission, his neurological examination was remarkable for ataxia, areflexia, and ophthalmoplegia, the typical triad of Miller Fisher syndrome (MFS). After confirming both diagnoses, the final diagnosis of CCPD was made. The challenges one may face to diagnose and treat CCPD urge sharing of similar cases to open the door for further extensive and thorough investigations and to encourage further studies and analysis of available data to come up with consolidated management guidelines for rare disorders.
Identifiants
pubmed: 34867717
doi: 10.3389/fneur.2021.730129
pmc: PMC8639527
doi:
Types de publication
Case Reports
Langues
eng
Pagination
730129Informations de copyright
Copyright © 2021 Alshamrani, Alyami, Alghanimi, Alajaji, Alkhaldi and Alamri.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurol Neurochir Pol. 2015;49(5):344-7
pubmed: 26377988
Neurology. 1993 Oct;43(10):1911-7
pubmed: 8413947
J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):241-3
pubmed: 7876862
Clin Neurol Neurosurg. 2002 Sep;104(4):377-9
pubmed: 12140109
J Neuroimmunol. 2019 Nov 15;336:577026
pubmed: 31450157
J Neurol. 2000 Dec;247(12):980-2
pubmed: 11200697
Iran J Neurol. 2019 Jan 5;18(1):35-37
pubmed: 31316735
Lancet. 2016 Aug 13;388(10045):717-27
pubmed: 26948435
Neurology. 2013 Aug 20;81(8):714-22
pubmed: 23884033
J Neurol Sci. 2016 Apr 15;363:182-7
pubmed: 27000248
J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):29-36
pubmed: 25673872
J Clin Neurosci. 2003 Jan;10(1):63-6
pubmed: 12464524
J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1784-6
pubmed: 15548509
Mult Scler Relat Disord. 2020 May;40:101943
pubmed: 31958671
Curr Opin Neurol. 2018 Dec;31(6):752-759
pubmed: 30300239