Origin and Dissemination of Altered El Tor Vibrio cholerae O1 Causing Cholera in Odisha, India: Two and Half Decade's View.
Odisha
V. cholerae O1
ctxB1 and ctxB7 genotypes
origin
spread
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
08
2021
accepted:
08
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
The origin, spread and molecular epidemiology of altered El Tor Vibrio cholerae O1 strains isolated from cholera outbreaks/surveillance studies between 1995 and 2019 from different district of Odisha were analyzed. The stock cultures of V. cholerae O1 strains from 1995 to 2019 were analyzed through molecular analysis using different PCR assays and pulse field gel electrophoresis (PFGE) analysis. The spread map (month, year and place) was constructed to locate the dissemination of altered El Tor variants of V. cholerae O1 in this region. A total of 13 cholera outbreaks were caused by V. cholerae O1 Ogawa biotype El Tor carrying ctxB1 and ctxB7 genotypes. The ctxB1 alleles of V. cholerae O1 mostly confined to the coastal areas, whereas the ctxB7 genotypes, though originating in the coastal region of Odisha, concentrated more in the tribal areas. The positive correlation between virulence-associated genes (VAGs) was found through Pearson's correlation model, indicative of a stronger association between the VAGs. The clonal relationship through PFGE between ctxB1 and ctxB7 genotypes of V. cholerae O1 strains exhibited 80% similarity indicating single- or multi-clonal evolution. It is evident from this study that the spread of multidrug-resistant V. cholerae O1-altered El Tor was dominant over the prototype El Tor strains in this region. The origin of altered El Tor variants of V. cholerae O1 occurred in the East Coast of Odisha established that the origin of cholera happened in the Gangetic belts of Bay of Bengal where all new variants of V. cholerae O1 might have originated from the Asian countries.
Identifiants
pubmed: 34867883
doi: 10.3389/fmicb.2021.757986
pmc: PMC8637270
doi:
Types de publication
Journal Article
Langues
eng
Pagination
757986Informations de copyright
Copyright © 2021 Pal, Behera, Nayak and Nayak.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer PK declared a shared affiliation with the authors to the handling editor at the time of the review
Références
Appl Environ Microbiol. 2006 Jun;72(6):4096-104
pubmed: 16751520
J Microbiol Immunol Infect. 2010 Apr;43(2):133-7
pubmed: 20457430
J Clin Microbiol. 2010 Nov;48(11):4283-6
pubmed: 20810767
Int Microbiol. 2004 Dec;7(4):285-9
pubmed: 15666250
Nature. 2019 Jan;565(7738):230-233
pubmed: 30602788
PLoS One. 2013;8(2):e56477
pubmed: 23431378
Front Public Health. 2019 Jul 23;7:203
pubmed: 31396501
J Clin Microbiol. 2010 Nov;48(11):3963-9
pubmed: 20826646
Infect Immun. 1998 Sep;66(9):4025-9
pubmed: 9712742
J Clin Microbiol. 2002 Sep;40(9):3296-9
pubmed: 12202569
Epidemiol Infect. 2013 Dec;141(12):2560-7
pubmed: 23461927
Foodborne Pathog Dis. 2006 Spring;3(1):51-8
pubmed: 16602979
J Clin Microbiol. 2006 Nov;44(11):4211-3
pubmed: 16957040
Int J Infect Dis. 2021 Apr;105:730-732
pubmed: 33741484
Jpn J Infect Dis. 2020 Jul 22;73(4):263-267
pubmed: 32115541
J Clin Microbiol. 2013 Jun;51(6):1909-12
pubmed: 23515546
Int J Infect Dis. 2010 May;14(5):e384-9
pubmed: 19781971
Bull World Health Organ. 1954;10(3):421-61
pubmed: 13160764
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2123-8
pubmed: 14766976
Clin Microbiol Infect. 2014 May;20(5):O292-3
pubmed: 24102849
Microbiol Immunol. 2008 Jun;52(6):314-7
pubmed: 18577166
Microbiol Mol Biol Rev. 1998 Dec;62(4):1301-14
pubmed: 9841673
J Med Microbiol. 2009 Feb;58(Pt 2):234-238
pubmed: 19141742
PLoS Negl Trop Dis. 2013;7(2):e2049
pubmed: 23459673
Front Public Health. 2018 Aug 30;6:238
pubmed: 30214899
Science. 2017 Nov 10;358(6364):785-789
pubmed: 29123067
Emerg Infect Dis. 2009 Feb;15(2):352-4
pubmed: 19193297
J Clin Microbiol. 2012 May;50(5):1733-6
pubmed: 22357499
Infect Genet Evol. 2020 Nov;85:104564
pubmed: 32979548
J Clin Microbiol. 2019 Apr 26;57(5):
pubmed: 30814268
Epidemiol Infect. 2002 Apr;128(2):131-8
pubmed: 12002529
J Bacteriol. 2010 Jul;192(13):3524-33
pubmed: 20348258
PLoS One. 2016 Aug 01;11(8):e0159794
pubmed: 27479360
Jpn J Infect Dis. 2018 Mar 22;71(2):99-103
pubmed: 29279443
Clin Microbiol Infect. 2014 May;20(5):373-9
pubmed: 24575898
Jpn J Infect Dis. 2017 Sep 25;70(5):549-553
pubmed: 28674316
Int J Infect Dis. 2015 Apr;33:45-9
pubmed: 25543097
J Clin Microbiol. 1993 Jan;31(1):22-5
pubmed: 7678018
BMC Infect Dis. 2019 Jan 21;19(1):76
pubmed: 30665342
Med Microbiol Immunol. 2016 Apr;205(2):195-200
pubmed: 26337047
Trends Microbiol. 2010 Jan;18(1):46-54
pubmed: 19942436
Emerg Infect Dis. 2009 Jan;15(1):131-2
pubmed: 19116078
Environ Microbiol Rep. 2021 Jun;13(3):355-363
pubmed: 33660421
Emerg Infect Dis. 2015 May;21(5):847-51
pubmed: 25897570
World J Microbiol Biotechnol. 2010 Feb;26(2):281-287
pubmed: 20495624
J Clin Microbiol. 2000 Nov;38(11):4145-51
pubmed: 11060082
Science. 2017 Nov 10;358(6364):789-793
pubmed: 29123068
PLoS Negl Trop Dis. 2015 Jun 04;9(6):e0003832
pubmed: 26043000
J Clin Microbiol. 2001 Jul;39(7):2594-7
pubmed: 11427575
Indian J Med Res. 2011 Apr;133:387-94
pubmed: 21537091