Neuro-Immunity and Gut Dysbiosis Drive Parkinson's Disease-Induced Pain.
Parkinson’s disease
dysbiosis
gut-brain axis
microbiota
neuro-immunity
nociceptor neurons
pain
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
08
2021
accepted:
21
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
9
2
2022
Statut:
epublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 1-2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD's motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD's non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity.
Identifiants
pubmed: 34868000
doi: 10.3389/fimmu.2021.759679
pmc: PMC8637106
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
759679Subventions
Organisme : CIHR
ID : 162211
Pays : Canada
Organisme : CIHR
ID : 461274
Pays : Canada
Organisme : CIHR
ID : 461275
Pays : Canada
Informations de copyright
Copyright © 2021 Roversi, Callai-Silva, Roversi, Griffith, Boutopoulos, Prediger and Talbot.
Déclaration de conflit d'intérêts
ST has an equity stake in Nocion Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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