CXCL13 Neutralization Attenuates Neuropsychiatric Manifestations in Lupus-Prone Mice.
CXCL13
MRL/lpr
SLE
neuropsychiatric lupus (NPSLE)
tertiary lymphoid structures
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
08
2021
accepted:
04
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
11
2
2022
Statut:
epublish
Résumé
Neuropsychiatric lupus (NPSLE), the nervous system presentation of systemic lupus erythematosus (SLE), remains challenging to treat due to its unclear pathogenesis and lack of available targeted therapies. A potential contributor to disease progression is brain tertiary lymphoid structures (TLS); these ectopic lymphoid follicles that can develop tissue-targeted antibodies have recently been described in the MRL/
Identifiants
pubmed: 34868008
doi: 10.3389/fimmu.2021.763065
pmc: PMC8633419
doi:
Substances chimiques
Chemokine CXCL13
0
Cxcl13 protein, mouse
0
STAT3 Transcription Factor
0
Stat3 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
763065Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105352
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007491
Pays : United States
Informations de copyright
Copyright © 2021 Huang, Stock and Putterman.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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