Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People.
Adult
Aged, 80 and over
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
BNT162 Vaccine
/ immunology
COVID-19
/ immunology
Female
Frailty
/ immunology
Humans
Immunogenicity, Vaccine
Immunosenescence
/ immunology
Male
Middle Aged
Nutritional Status
/ immunology
SARS-CoV-2
/ immunology
T-Lymphocytes
/ immunology
SARS – CoV – 2
T cells response
mRNA vaccination
older people and ageing
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
09
2021
accepted:
19
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
4
1
2022
Statut:
epublish
Résumé
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell response. We quantified S1-specific IgG, neutralizing antibody titers, total specific IFNγ-secreting T cells by ELISpot, and functionality of CD4
Identifiants
pubmed: 34868051
doi: 10.3389/fimmu.2021.778679
pmc: PMC8637126
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
778679Informations de copyright
Copyright © 2021 Demaret, Corroyer-Simovic, Alidjinou, Goffard, Trauet, Miczek, Vuotto, Dendooven, Huvent-Grelle, Podvin, Dreuil, Faure, Deplanque, Bocket, Duhamel, Labreuche, Sobaszek, Hisbergues, Puisieux, Labalette and Lefèvre.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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