Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives.
Animals
Biomarkers
Clinical Decision-Making
Combined Modality Therapy
Cytokines
/ antagonists & inhibitors
Disease Management
Disease Susceptibility
Host-Pathogen Interactions
/ immunology
Humans
Immune System
/ cytology
Immunomodulation
Molecular Targeted Therapy
Periodontitis
/ diagnosis
Treatment Outcome
drug therapy
gene therapy
immune microenvironment (IME)
immunomodulation
microbial therapy
periodontitis
stem cell therapy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
09
2021
accepted:
02
11
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis.
Identifiants
pubmed: 34868054
doi: 10.3389/fimmu.2021.781378
pmc: PMC8640126
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
781378Informations de copyright
Copyright © 2021 Yang, Pang, Li, Chen and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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