A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19.
COVID-19
SARS-CoV-2
intestinal microbiota
microbiome
severity
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2021
accepted:
29
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the relevance of the gut microbiome on COVID-19 severity needs to be clarified. In this prospective study, we analyzed the gut microbiome of 212 patients of a tertiary care hospital (117 patients infected with SARS-CoV-2 and 95 SARS-CoV-2 negative patients) using
Identifiants
pubmed: 34869058
doi: 10.3389/fcimb.2021.747816
pmc: PMC8635721
doi:
Substances chimiques
Anti-Inflammatory Agents
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
747816Informations de copyright
Copyright © 2021 Reinold, Farahpour, Fehring, Dolff, Konik, Korth, van Baal, Hoffmann, Buer, Witzke, Westendorf and Kehrmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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