Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function.
DNA methylation
adoptive cell therapy
advanced therapy medicinal products
biomarker
good manufacturing practice
regulatory T cells
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
08
2021
accepted:
12
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and during autoimmune disease. To reach sufficient cell yield for treatment,
Identifiants
pubmed: 34869339
doi: 10.3389/fcell.2021.751590
pmc: PMC8639223
doi:
Types de publication
Journal Article
Langues
eng
Pagination
751590Informations de copyright
Copyright © 2021 Ou, Hamo, Schulze, Roemhild, Kaiser, Gasparoni, Salhab, Zarrinrad, Amini, Schlickeiser, Streitz, Walter, Volk, Schmueck-Henneresse, Reinke and Polansky.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
Front Immunol. 2018 Feb 13;9:252
pubmed: 29487602
Nat Rev Immunol. 2020 Mar;20(3):158-172
pubmed: 31811270
Immunity. 2011 Mar 25;34(3):435-47
pubmed: 21419664
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Nat Genet. 2018 Apr;50(4):591-602
pubmed: 29610480
Transplantation. 2017 Feb;101(2):302-309
pubmed: 28118317
Immunity. 2014 Feb 20;40(2):289-302
pubmed: 24530057
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):
pubmed: 34285077
Nature. 2019 Jul;571(7764):270-274
pubmed: 31207604
Cell. 2017 Jun 29;170(1):142-157.e19
pubmed: 28648661
Front Immunol. 2019 Feb 05;10:150
pubmed: 30804944
Curr Pharm Des. 2013;19(9):1680-98
pubmed: 23061726
J Immunol. 2006 Dec 1;177(11):8095-102
pubmed: 17114484
Immunity. 2021 Apr 13;54(4):702-720.e17
pubmed: 33789089
Aging (Albany NY). 2011 Sep;3(9):873-88
pubmed: 22025769
Eur J Immunol. 2005 May;35(5):1336-41
pubmed: 15827965
Sci Transl Med. 2011 May 18;3(83):83ra41
pubmed: 21593401
Immunity. 2020 Jun 16;52(6):1119-1132.e4
pubmed: 32362325
Epigenetics Chromatin. 2018 Jun 29;11(1):37
pubmed: 29958539
Sci Transl Med. 2015 Nov 25;7(315):315ra189
pubmed: 26606968
Mol Cell Pharmacol. 2010 Jan 1;2(3):111-116
pubmed: 20686680
Br J Haematol. 2019 Oct;187(1):25-38
pubmed: 31418827
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6248-53
pubmed: 27185917
Epigenetics Chromatin. 2015 Jan 27;8:6
pubmed: 25972926
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Mol Ther Methods Clin Dev. 2018 Jan 31;8:198-209
pubmed: 29552576
J Thorac Dis. 2019 Mar;11(3):857-864
pubmed: 31019774
Nat Rev Immunol. 2009 Feb;9(2):83-9
pubmed: 19114986
J Immunol. 2015 Jul 1;195(1):145-55
pubmed: 25994968
J Immunol. 2009 May 1;182(9):5203-7
pubmed: 19380765
J Exp Med. 2017 Jun 5;214(6):1593-1606
pubmed: 28490440
Epigenetics Chromatin. 2020 Oct 2;13(1):39
pubmed: 33008446
Annu Rev Immunol. 2019 Apr 26;37:145-171
pubmed: 30526160
J Clin Invest. 2012 Jul;122(7):2395-404
pubmed: 22684103
Eur J Immunol. 2007 Jan;37(1):129-38
pubmed: 17154262
Clin Exp Immunol. 2019 Jul;197(1):52-63
pubmed: 30913302
Immunity. 2016 Nov 15;45(5):1148-1161
pubmed: 27851915
Sci Rep. 2017 Feb 22;7:43003
pubmed: 28223693
Genome Res. 2013 Mar;23(3):555-67
pubmed: 23325432
Immunol Invest. 2007;36(5-6):607-28
pubmed: 18161521
J Immunol Methods. 2007 Apr 30;322(1-2):1-11
pubmed: 17368474
Blood. 2005 Jun 15;105(12):4743-8
pubmed: 15746082
Immunity. 2014 Nov 20;41(5):853-65
pubmed: 25517617
Cell Immunol. 2020 Nov;357:104214
pubmed: 32977154
BMJ. 2020 Oct 21;371:m3734
pubmed: 33087345
Front Immunol. 2019 Dec 17;10:2901
pubmed: 31921162
Genes Immun. 2016 Jul;17(5):283-97
pubmed: 27170561
Nat Immunol. 2017 Oct;18(10):1160-1172
pubmed: 28783152
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
PLoS Genet. 2018 Nov 29;14(11):e1007802
pubmed: 30496290
Front Immunol. 2018 Jan 15;8:1844
pubmed: 29379498
Nat Rev Drug Discov. 2018 Nov;17(11):823-844
pubmed: 30310234
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Sci Transl Med. 2015 Sep 9;7(304):304ps18
pubmed: 26355029
Cell Signal. 2011 Jan;23(1):249-58
pubmed: 20851766
Clin Cancer Res. 2018 Sep 15;24(18):4529-4538
pubmed: 29712685
Curr Opin Virol. 2013 Jun;3(3):371-6
pubmed: 23747121
J Exp Med. 1991 Apr 1;173(4):931-9
pubmed: 1826128
Bioinformatics. 2015 Jul 15;31(14):2382-3
pubmed: 25765347
Lancet. 2020 May 23;395(10237):1627-1639
pubmed: 32446407
J Clin Invest. 2015 Nov 2;125(11):4053-62
pubmed: 26413872
Eur J Immunol. 2009 Apr;39(4):1088-97
pubmed: 19283780
Blood. 2007 Oct 15;110(8):2983-90
pubmed: 17644734
Nature. 2011 Mar 3;471(7336):68-73
pubmed: 21289626
Exp Ther Med. 2019 Oct;18(4):2443-2450
pubmed: 31555356
Immunity. 2013 Nov 14;39(5):949-62
pubmed: 24238343
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Nature. 2019 Jul;571(7764):211-218
pubmed: 31207603
Blood. 2011 Sep 29;118(13):e82-92
pubmed: 21778340
Cell Transplant. 2011;20(11-12):1747-58
pubmed: 21457615
J Immunol. 2017 Nov 1;199(9):3158-3175
pubmed: 28947543
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
Front Immunol. 2019 Jan 31;10:43
pubmed: 30804926
J Immunol. 1995 Feb 15;154(4):1531-42
pubmed: 7836739
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Annu Rev Immunol. 1998;16:27-55
pubmed: 9597123
Oncoimmunology. 2013 Apr 1;2(4):e23849
pubmed: 23734331
JCI Insight. 2018 Jan 25;3(2):
pubmed: 29367462
Expert Rev Clin Immunol. 2019 Jul;15(7):777-789
pubmed: 31104510
J Transl Med. 2009 Oct 22;7:89
pubmed: 19849846
Science. 2016 Dec 2;354(6316):1165-1169
pubmed: 27789799
Science. 2021 Apr 2;372(6537):
pubmed: 33795428
Front Immunol. 2019 Jul 10;10:1342
pubmed: 31354695
J Immunol. 2006 Dec 15;177(12):8338-47
pubmed: 17142730
Genome Biol. 2018 Sep 28;19(1):150
pubmed: 30266094
Methods Mol Biol. 2011;707:21-37
pubmed: 21287326
BMC Med Genomics. 2020 Jan 6;13(1):4
pubmed: 31906954
Cell Mol Life Sci. 2012 May;69(10):1615-23
pubmed: 22466672
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Cell. 2016 Sep 8;166(6):1500-1511.e9
pubmed: 27610572
Nat Immunol. 2020 May;21(5):578-587
pubmed: 32231298
Genome Res. 2012 Feb;22(2):246-58
pubmed: 22156296
Nat Biotechnol. 2009 Apr;27(4):361-8
pubmed: 19329998