Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.
Hox
chromatin accessibility
cis-regulatory modules (CRMs)
protein-protein interaction
transcription factor
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
09
2021
accepted:
28
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
Metazoans differentially express multiple Hox transcription factors to specify diverse cell fates along the developing anterior-posterior axis. Two challenges arise when trying to understand how the Hox transcription factors regulate the required target genes for morphogenesis: First, how does each Hox factor differ from one another to accurately activate and repress target genes required for the formation of distinct segment and regional identities? Second, how can a Hox factor that is broadly expressed in many tissues within a segment impact the development of specific organs by regulating target genes in a cell type-specific manner? In this review, we highlight how recent genomic, interactome, and
Identifiants
pubmed: 34869389
doi: 10.3389/fcell.2021.787339
pii: 787339
pmc: PMC8635045
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
787339Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM079428
Pays : United States
Informations de copyright
Copyright © 2021 Cain and Gebelein.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nature. 1998 Apr 16;392(6677):723-6
pubmed: 9565034
Genome Biol. 2004;5(12):R96
pubmed: 15575970
Nat Rev Genet. 2005 Dec;6(12):893-904
pubmed: 16341070
Cell. 1989 May 5;57(3):367-78
pubmed: 2566383
Curr Top Dev Biol. 2009;88:63-101
pubmed: 19651302
Science. 2003 Dec 5;302(5651):1727-36
pubmed: 14605208
BMC Dev Biol. 2012 Oct 22;12:29
pubmed: 23088713
Nature. 2004 Oct 7;431(7009):653-9
pubmed: 15470419
Dev Cell. 2002 Oct;3(4):487-98
pubmed: 12408801
Pediatr Res. 1997 Oct;42(4):421-9
pubmed: 9380431
Genome Biol. 2019 Jun 3;20(1):115
pubmed: 31159833
Nat Rev Genet. 2009 Sep;10(9):605-16
pubmed: 19668247
Adv Genet. 2011;76:55-91
pubmed: 22099692
Nature. 1987 Feb 26-Mar 4;325(6107):816-8
pubmed: 3821869
Genetics. 1980 Jan;94(1):115-33
pubmed: 17248988
Cell. 2014 Nov 20;159(5):1212-1226
pubmed: 25416956
PLoS Genet. 2018 Apr 4;14(4):e1007289
pubmed: 29617378
Nat Commun. 2020 Mar 13;11(1):1388
pubmed: 32170121
Dev Cell. 2011 Oct 18;21(4):611-26
pubmed: 22014521
Genes Dev. 2020 Dec 1;34(23-24):1680-1696
pubmed: 33184220
Cell. 1992 Oct 30;71(3):437-50
pubmed: 1358457
Nature. 1978 Dec 7;276(5688):565-70
pubmed: 103000
Nat Commun. 2020 May 19;11(1):2491
pubmed: 32427842
Nature. 1995 May 4;375(6526):58-61
pubmed: 7723843
Development. 2002 Jun;129(12):2957-63
pubmed: 12050142
PLoS One. 2010 May 25;5(5):e10820
pubmed: 20520839
Cancers (Basel). 2019 Mar 07;11(3):
pubmed: 30866492
Dev Biol. 2006 Mar 15;291(2):193-206
pubmed: 16515781
Curr Opin Genet Dev. 1998 Aug;8(4):423-9
pubmed: 9729718
Cell. 1984 Jun;37(2):403-8
pubmed: 6327065
Curr Top Dev Biol. 2009;88:1-33
pubmed: 19651300
Genes Dev. 1997 Nov 15;11(22):3072-82
pubmed: 9367988
Mol Cell. 2004 May 21;14(4):465-77
pubmed: 15149596
Curr Top Dev Biol. 2013;104:113-48
pubmed: 23587240
Genes Dev. 2003 Aug 15;17(16):2060-72
pubmed: 12923056
Dev Cell. 2004 Jun;6(6):737-8
pubmed: 15177017
Development. 2020 Nov 23;147(22):
pubmed: 33028607
Genes Dev. 1997 Feb 15;11(4):436-50
pubmed: 9042858
Dev Cell. 2014 Jan 27;28(2):203-11
pubmed: 24480644
Genetics. 1986 Nov;114(3):919-42
pubmed: 3098627
Elife. 2018 Sep 24;7:
pubmed: 30247122
Nat Commun. 2021 Aug 26;12(1):5136
pubmed: 34446717
Cell. 2008 Jun 27;133(7):1266-76
pubmed: 18585359
Mol Cell Biol. 2007 Nov;27(21):7661-8
pubmed: 17785448
Mol Cell. 2002 Mar;9(3):587-600
pubmed: 11931766
Nat Methods. 2011 Jun;8(6):478-80
pubmed: 21516116
Dev Cell. 2008 Aug;15(2):298-308
pubmed: 18694568
Mol Cell Biol. 1996 Jun;16(6):2678-88
pubmed: 8649375
Curr Biol. 2021 Oct 11;31(19):4246-4255.e4
pubmed: 34358443
Nature. 2018 Oct;562(7725):76-81
pubmed: 30250250
Annu Rev Cell Dev Biol. 2019 Oct 6;35:357-379
pubmed: 31283382
J Dev Biol. 2021 Feb 03;9(1):
pubmed: 33546292
Science. 1983 Jul 1;221(4605):23-9
pubmed: 17737996
Cell. 2013 Jan 17;152(1-2):327-39
pubmed: 23332764
Epigenetics Chromatin. 2016 Jan 08;9:1
pubmed: 26753000
Front Cell Dev Biol. 2021 Aug 11;9:718308
pubmed: 34458272
Nature. 2020 Apr;580(7803):402-408
pubmed: 32296183
Dev Biol. 2019 Jan 15;445(2):226-236
pubmed: 30468713
Dev Biol. 2021 Sep;477:284-292
pubmed: 34102167
Annu Rev Genet. 2020 Nov 23;54:367-385
pubmed: 32886547
Nature. 1984 Mar 29-Apr 4;308(5958):428-33
pubmed: 6323992
Cell. 2020 Dec 23;183(7):2020-2035.e16
pubmed: 33326746
Mol Genet Metab. 2014 Jan;111(1):4-15
pubmed: 24239177
EMBO J. 1989 May;8(5):1497-505
pubmed: 2569969
Genome Biol. 2011;12(4):109
pubmed: 21489330
Chromosoma. 2016 Jun;125(3):497-521
pubmed: 26464018
Trends Genet. 2016 Jun;32(6):334-347
pubmed: 27066866
Cell Rep. 2012 Apr 19;1(4):350-9
pubmed: 22523743
Development. 2012 May;139(9):1611-9
pubmed: 22438572
Dev Biol. 2004 Dec 15;276(2):541-51
pubmed: 15581884
Semin Cell Biol. 1990 Jun;1(3):219-27
pubmed: 1983316
EMBO J. 1999 Jan 4;18(1):198-211
pubmed: 9878063
Genes Dev. 2021 Jan 1;35(1-2):157-174
pubmed: 33334823
Bioessays. 1997 Aug;19(8):661-4
pubmed: 9264246
J Dev Biol. 2016 Jun;4(2):
pubmed: 27583210
Mol Cell. 2019 Sep 5;75(5):921-932.e6
pubmed: 31303471
Nature. 2005 Oct 20;437(7062):1173-8
pubmed: 16189514
Genes Dev. 2014 Dec 15;28(24):2679-92
pubmed: 25512556
Genes Dev. 1994 Jul 15;8(14):1678-92
pubmed: 7958848
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21330-5
pubmed: 23236164
Nucleic Acids Res. 1994 Feb 11;22(3):376-82
pubmed: 7907418
Dev Biol. 2009 Nov 1;335(1):156-65
pubmed: 19716816
Dev Biol. 2010 Jul 1;343(1-2):154-66
pubmed: 20398649
PLoS Genet. 2016 Apr 08;12(4):e1005981
pubmed: 27058369
Cell Rep. 2019 Apr 16;27(3):955-970.e7
pubmed: 30995488
PLoS Genet. 2011 Oct;7(10):e1002302
pubmed: 22046139
Cell. 2015 Jan 15;160(1-2):191-203
pubmed: 25557079
Cell. 2011 Dec 9;147(6):1270-82
pubmed: 22153072
Cell Rep. 2018 Aug 28;24(9):2221-2230
pubmed: 30157419
Dev Cell. 2013 Nov 11;27(3):306-18
pubmed: 24229644