Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure.
ADHF, acute decompensated heart failure
CVP, central venous pressure
EVLW, extravascular lung water
acute decompensated heart failure
decongestion
interstitial
lymphatic
pulmonary edema
thoracic duct
volume overload
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
20
07
2021
revised:
30
09
2021
accepted:
30
09
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
7
12
2021
Statut:
epublish
Résumé
Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%,
Identifiants
pubmed: 34869951
doi: 10.1016/j.jacbts.2021.09.008
pii: S2452-302X(21)00303-X
pmc: PMC8617571
doi:
Types de publication
Journal Article
Langues
eng
Pagination
872-881Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
WhiteSwell funded the studies. Drs Abraham, Jonas, and Dongaonkar have received consulting fees from WhiteSwell. Drs Geist, Ueyama, Render, Youngblood, Muir, Hamlin, and del Rio have received research fees from WhiteSwell for the conduct of the animal studies.
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