Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters.
Cellular physiology
Microbiology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
02
08
2021
revised:
15
11
2021
accepted:
23
11
2021
pubmed:
7
12
2021
medline:
7
12
2021
entrez:
6
12
2021
Statut:
ppublish
Résumé
The golden hamster model of SARS-CoV-2 infection recapitulates key characteristics of COVID-19. In this work we examined the influence of the route of exposure, sex, and age on SARS-CoV-2 pathogenesis in hamsters. We report that delivery of SARS-CoV-2 by a low- versus high-volume intranasal or intragastric route results in comparable viral titers in the lung and viral shedding. However, low-volume intranasal exposure results in milder weight loss, whereas intragastric exposure leads to a diminished capacity to regain body weight. Male hamsters, and particularly older male hamsters, display an impaired capacity to recover from illness and delayed viral clearance. These factors were found to influence the nature of the host inflammatory cytokine response but had a minimal effect on the quality and durability of the humoral immune response and susceptibility to re-infection. These data further elucidate key factors that impact pre-clinical challenge studies carried out in the hamster model of COVID-19.
Identifiants
pubmed: 34870132
doi: 10.1016/j.isci.2021.103530
pii: S2589-0042(21)01501-7
pmc: PMC8627009
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103530Informations de copyright
Crown Copyright © 2021.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Curr Protoc Microbiol. 2020 Jun;57(1):ecpmc105
pubmed: 32475066
Ann Hematol. 2020 Jun;99(6):1205-1208
pubmed: 32296910
J Virol. 2011 May;85(10):4673-8
pubmed: 21411541
Microorganisms. 2020 Jul 24;8(8):
pubmed: 32722020
Gastroenterology. 2020 Jul;159(1):81-95
pubmed: 32251668
Am J Gastroenterol. 2020 May;115(5):766-773
pubmed: 32287140
Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L833-9
pubmed: 11880310
Nat Immunol. 2021 Jan;22(1):86-98
pubmed: 33235385
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
PLoS Pathog. 2011 Dec;7(12):e1002426
pubmed: 22194683
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Nature. 2021 Mar;591(7849):293-299
pubmed: 33494095
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Allergy Clin Immunol. 2020 Jul;146(1):110-118
pubmed: 32294485
N Engl J Med. 2020 Aug 6;383(6):592-594
pubmed: 32402157
J Immunol. 2017 May 15;198(10):4046-4053
pubmed: 28373583
Sci Immunol. 2020 May 13;5(47):
pubmed: 32404436
Cell. 2020 Aug 6;182(3):744-753.e4
pubmed: 32553273
Clin Infect Dis. 2020 Dec 3;71(9):2428-2446
pubmed: 32215622
Nat Commun. 2021 Jun 14;12(1):3612
pubmed: 34127676
Nat Commun. 2018 Sep 19;9(1):3811
pubmed: 30232333
Clin Infect Dis. 2020 Nov 5;71(8):1937-1942
pubmed: 32301997
Cell Host Microbe. 2020 Jul 8;28(1):124-133.e4
pubmed: 32485164
Gut. 2020 Jun;69(6):1002-1009
pubmed: 32213556
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28348037
PLoS Pathog. 2010 Feb 05;6(2):e1000756
pubmed: 20140198
J Transl Med. 2020 May 20;18(1):206
pubmed: 32434518
J Immunol. 2009 Dec 1;183(11):6883-92
pubmed: 19923474
Nature. 2020 Jul;583(7818):834-838
pubmed: 32408338
Science. 2020 Sep 25;369(6511):1603-1607
pubmed: 32732280
Lancet. 2020 Feb 22;395(10224):e39
pubmed: 32035510
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
PLoS Pathog. 2014 Mar 13;10(3):e1004001
pubmed: 24626480
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16587-16595
pubmed: 32571934
J Assoc Med Microbiol Infect Dis Can. 2020 Dec 31;5(4):223-234
pubmed: 36340059
NPJ Vaccines. 2021 Jan 25;6(1):16
pubmed: 33495468
JAMA. 2020 Apr 14;323(14):1335
pubmed: 32181795
J Gen Virol. 2021 Mar;102(3):
pubmed: 33612147
Sci Rep. 2020 Sep 29;10(1):16007
pubmed: 32994418
Cell Host Microbe. 2020 May 13;27(5):704-709.e2
pubmed: 32259477
Science. 2020 May 29;368(6494):1012-1015
pubmed: 32303590
Nature. 2020 Jul;583(7818):830-833
pubmed: 32380511
Sci Adv. 2017 Nov 15;3(11):eaao4966
pubmed: 29152574
Science. 2020 May 29;368(6494):1016-1020
pubmed: 32269068
Nature. 2020 Oct;586(7830):560-566
pubmed: 32854108
Nat Rev Immunol. 2020 Jul;20(7):442-447
pubmed: 32528136
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Nat Commun. 2020 Nov 17;11(1):5838
pubmed: 33203860
JAMA Netw Open. 2021 Mar 1;4(3):e211085
pubmed: 33688964
Nature. 2020 Dec;588(7837):315-320
pubmed: 32846427
Crit Rev Immunol. 2005;25(2):75-102
pubmed: 15952931
PLoS Pathog. 2021 May 19;17(5):e1009585
pubmed: 34010360
Front Immunol. 2020 Dec 18;11:614256
pubmed: 33391285
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
EBioMedicine. 2020 May;55:102763
pubmed: 32361250
Science. 2020 Jun 26;368(6498):1422-1424
pubmed: 32461212
N Engl J Med. 2003 Dec 18;349(25):2431-41
pubmed: 14681510
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965
pubmed: 33037151
Nature. 2020 Sep;585(7824):268-272
pubmed: 32396922
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E562-E567
pubmed: 32726128
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
Viruses. 2020 Jul 20;12(7):
pubmed: 32698441
Antimicrob Agents Chemother. 2005 Oct;49(10):3991-6
pubmed: 16189071
Science. 2020 Dec 18;370(6523):1464-1468
pubmed: 33184236
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Cell Rep Med. 2020 Oct 20;1(7):100121
pubmed: 32984855
Signal Transduct Target Ther. 2020 Oct 19;5(1):157
pubmed: 32814760
Gastroenterology. 2020 May;158(6):1831-1833.e3
pubmed: 32142773
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508