Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing.

adverse analytical finding anti-doping minimum reporting level prescription medication rule violation

Journal

Frontiers in sports and active living
ISSN: 2624-9367
Titre abrégé: Front Sports Act Living
Pays: Switzerland
ID NLM: 101765780

Informations de publication

Date de publication:
2021
Historique:
received: 07 04 2021
accepted: 25 10 2021
entrez: 6 12 2021
pubmed: 7 12 2021
medline: 7 12 2021
Statut: epublish

Résumé

This paper describes nine instances of positive anti-doping tests that could be accounted for by the use of permitted generic prescription drugs contaminated with diuretics, which are prohibited in sport at all times under the WADA Prohibited List. The contamination levels found in the medications are reported and were below FDA limits for manufacturers that are based primarily on safety considerations. These cases demonstrate that great care must be taken to identify the source of low-level anti-doping positives for diuretics reported by WADA-accredited laboratories, and possibly other prohibited substances as well, in order to avoid sanctioning innocent athletes. An evaluation of the cases in this paper supports an approach which establishes a laboratory minimum reporting level (MRL) for diuretics found most commonly in medications. A global consensus after extensive review of similar anti-doping cases has resulted in implementation of a recently announced solution regarding potential diuretic contamination cases.

Identifiants

pubmed: 34870192
doi: 10.3389/fspor.2021.692244
pmc: PMC8635962
doi:

Types de publication

Journal Article

Langues

eng

Pagination

692244

Informations de copyright

Copyright © 2021 Eichner, Lewis, Leonard, Wagoner, Eichner and Fedoruk.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

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Forensic Sci Int. 2016 Oct;267:166-172
pubmed: 27611956
Nutrients. 2017 Oct 04;9(10):
pubmed: 28976928
JAMA Netw Open. 2018 Oct 5;1(6):e183337
pubmed: 30646238

Auteurs

Amy Eichner (A)

United States Anti-Doping Agency, Colorado Springs, CO, United States.

Laura A Lewis (LA)

United States Anti-Doping Agency, Colorado Springs, CO, United States.

Bridget Leonard (B)

United States Anti-Doping Agency, Colorado Springs, CO, United States.

Ryan M Van Wagoner (RMV)

Sports Medicine and Research Testing Laboratory, Salt Lake City, UT, United States.

Daniel Eichner (D)

Sports Medicine and Research Testing Laboratory, Salt Lake City, UT, United States.

Matthew N Fedoruk (MN)

United States Anti-Doping Agency, Colorado Springs, CO, United States.

Classifications MeSH