Impact of different pathogen reduction technologies on the biochemistry, function, and clinical effectiveness of platelet concentrates: An updated view during a pandemic.
in vitro quality
pathogen reduction technologies
platelet concentrates
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
03
09
2021
received:
24
04
2021
accepted:
06
10
2021
pubmed:
7
12
2021
medline:
28
1
2022
entrez:
6
12
2021
Statut:
ppublish
Résumé
Standard platelet concentrates (PCs) stored at 22°C have a limited shelf life of 5 days. Because of the storage temperature, bacterial contamination of PCs can result in life-threatening infections in transfused patients. The potential of blood components to cause infections through contaminating pathogens or transmitting blood-borne diseases has always been a concern. The current safety practice to prevent pathogen transmission through blood transfusion starts with a stringent screening of donors and regulated testing of blood samples to ensure that known infections cannot reach transfusion products. Pathogen reduction technologies (PRTs), initially implemented to ensure the safety of plasma products, have been adapted to treat platelet products. In addition to reducing bacterial contamination, PRT applied to PCs can extend their shelf life up to 7 days, alleviating the impact of their shortage, while providing an additional safety layer against emerging blood-borne infectious diseases. While a deleterious action of PRTs in quantitative and qualitative aspects of plasma is accepted, the impact of PRTs on the quality, function, and clinical efficacy of PCs has been under constant examination. The potential of PRTs to prevent the possibility of new emerging diseases to reach cellular blood components has been considered more hypothetical than real. In 2019, a coronavirus-related disease (COVID-19) became a pandemic. This episode should help when reconsidering the possibility of future blood transmissible threats. The following text intends to evaluate the impact of different PRTs on the quality, function, and clinical effectiveness of platelets within the perspective of a developing pandemic.
Identifiants
pubmed: 34870335
doi: 10.1111/trf.16747
pmc: PMC9300014
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-246Subventions
Organisme : 2017-SGR671 from Generalitat de Catalunya
Organisme : CERCA Program of the Generalitat de Catalunya
Organisme : FIS PI19/00888 from the Instituto de Salud Carlos III, Spanish Government
Organisme : German José Carreras Leukaemia Foundation (03R/2019)
Organisme : Integrated Project in Health Institutes (PIE15/00027)
Informations de copyright
© 2021 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.
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