Serotonin system-associated genetic and epigenetic changes in pedophilia and child sexual offending.

Child sexual offending DNA methylation Rates Pedophilia Serotonergic system

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
27 Nov 2021
Historique:
received: 29 07 2021
revised: 19 11 2021
accepted: 24 11 2021
pubmed: 7 12 2021
medline: 7 12 2021
entrez: 6 12 2021
Statut: aheadofprint

Résumé

Numerous studies have shown associations between anomalies of the serotonergic system and impulsive behavior, depression, or traumatic life events. However, it is currently unknown, whether pedophilia or child sexual offending (CSO) is also related to alterations of the serotonergic system. Using a two by two factorial paradigm within a multisite consortium (NeMUP*) study cohort, we analyzed whether the SLC6A4-linked polymorphic region (SLC6A4LPR) or the SLC6A4 (transporter) and HTR3A (receptor) promotor methylation rates differed with regard to a pedophilic preference and/or child sexual offending. Methylation rates of HTR3A showed significant differences between child sexual offenders and non-offenders, with child sexual offenders showing lower methylation rates. Moreover, HTR3A methylation rates showed significant negative correlations with the Child Trauma Questionnaire (CTQ) subscale "sexual violence", and the number of sexual offenses committed. Interestingly, we also found pedophilia-related alterations in 5HT

Identifiants

DOI: 10.1016/j.jpsychires.2021.11.042 PMID: 34871921
pubmed: 34871921
pii: S0022-3956(21)00699-3
doi: 10.1016/j.jpsychires.2021.11.042
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

60-69

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Kirsten Jahn (K)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Laboratory of Molecular Psychiatry, Hannover, Medical School, Hannover, Germany.

Bernadett Kurz (B)

Division of Forensic Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.

Christopher Sinke (C)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Division of Clinical Psychology and Sexual Medicine, Hannover, Medical School, Hannover, Germany.

Jonas Kneer (J)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Division of Clinical Psychology and Sexual Medicine, Hannover, Medical School, Hannover, Germany.

Ole Riemer (O)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Laboratory of Molecular Psychiatry, Hannover, Medical School, Hannover, Germany.

Jorge Ponseti (J)

Institute of Sexual Medicine and Forensic Psychiatry and Psychotherapy, Medical School, Kiel University, Kiel, Germany.

Martin Walter (M)

Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany.

Klaus M Beier (KM)

Institute of Sexology and Sexual Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Henrik Walter (H)

Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Helge Frieling (H)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Laboratory of Molecular Psychiatry, Hannover, Medical School, Hannover, Germany; Center for Systems Neurosciences, Hannover, Germany.

Boris Schiffer (B)

Division of Forensic Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.

Tillmann H C Kruger (THC)

Department of Psychiatry, Social Psychiatry and Psychotherapy, Division of Clinical Psychology and Sexual Medicine, Hannover, Medical School, Hannover, Germany; Center for Systems Neurosciences, Hannover, Germany. Electronic address: Krueger.Tillmann@mh-hannover.de.

Classifications MeSH