Rapid pathogen-specific recruitment of immune effector cells in the skin by secreted toxins.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
13
02
2020
accepted:
29
10
2021
pubmed:
8
12
2021
medline:
23
2
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
Swift recruitment of phagocytic leucocytes is critical in preventing infection when bacteria breach through the protective layers of the skin. According to canonical models, this occurs via an indirect process that is initiated by contact of bacteria with resident skin cells and which is independent of the pathogenic potential of the invader. Here we describe a more rapid mechanism of leucocyte recruitment to the site of intrusion of the important skin pathogen Staphylococcus aureus that is based on direct recognition of specific bacterial toxins, the phenol-soluble modulins (PSMs), by circulating leucocytes. We used a combination of intravital imaging, ear infection and skin abscess models, and in vitro gene expression studies to demonstrate that this early recruitment was dependent on the transcription factor EGR1 and contributed to the prevention of infection. Our findings refine the classical notion of the non-specific and resident cell-dependent character of the innate immune response to bacterial infection by demonstrating a pathogen-specific high-alert mechanism involving direct recruitment of immune effector cells by secreted bacterial products.
Identifiants
pubmed: 34873293
doi: 10.1038/s41564-021-01012-9
pii: 10.1038/s41564-021-01012-9
pmc: PMC8732318
mid: NIHMS1752914
doi:
Substances chimiques
Bacterial Toxins
0
Virulence Factors
0
staphylococcal delta toxin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-72Subventions
Organisme : Intramural NIH HHS
ID : ZIA AI001171
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001079
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010725
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AI000904
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI000904
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
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