Multi-drug-resistant tuberculosis clusters in Mpumalanga province, South Africa, 2013-2016: A spatial analysis.
MDR-TB
clustering
geographic information systems
hotspot
Journal
Tropical medicine & international health : TM & IH
ISSN: 1365-3156
Titre abrégé: Trop Med Int Health
Pays: England
ID NLM: 9610576
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
pubmed:
8
12
2021
medline:
4
3
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
To identify spatial clusters with unusually high levels of MDR-TB, which are highly unlikely to have arisen by chance in Mpumalanga Province, South Africa. Home addresses of all MDR-TB patients were collected from four MDR-TB facilities from 2013 to 2016. We mapped all addresses, linking them to the nearest ward with population estimates. A spatial analysis was conducted using kernel density in ArcGIS to estimate and map the distribution of the disease and used Gertis-Ord Gi to test for significant clustering. A total of 4065 MDR-TB patients were mapped. Ten significant clusters (p-value <0.05) were found across the province in six sub-districts: Mbombela, Nkomazi, Emalahleni, Govan Mbeki, Lekwa and Mkhondo. Mbombela has the highest number of significant clusters. The central region did not have any MDR-TB clusters. There is clear evidence of MDR-TB clustering in Mpumalanga. This calls for concentrated TB prevention efforts and proper allocation of resources. Further investigations are needed to identify MDR-TB predictors.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-191Informations de copyright
© 2021 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd.
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