The origin and repopulation of microglia.
immune cells
inflammatory diseases
microglia
origin
regeneration
Journal
Developmental neurobiology
ISSN: 1932-846X
Titre abrégé: Dev Neurobiol
Pays: United States
ID NLM: 101300215
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
17
10
2021
received:
30
06
2021
accepted:
20
11
2021
pubmed:
8
12
2021
medline:
1
4
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
Microglia are important immune cells in the central nervous system. There is growing interest in the study of microglia due to their implication in neurodevelopment, acute injury, and neuropsychiatric disorders. They undergo birth, death, and regeneration during the lifetime. Although data on the ontogeny of microglia have been studied for decades, the birth and repopulation of microglia remain legendary and mysterious. In this review, we discuss recent studies that provide new insights into the origin and regeneration of microglia. Modulating the development of microglia may offer new therapeutic opportunities for preventing deleterious effects of inflammation and controlling excessive inflammation in brain diseases.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-124Informations de copyright
© 2021 Wiley Periodicals LLC.
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