Prospective Paired Comparison of 123I-FP-CIT SPECT Images Obtained With a 360°-CZT and a Conventional Camera.


Journal

Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109

Informations de publication

Date de publication:
01 01 2022
Historique:
entrez: 7 12 2021
pubmed: 8 12 2021
medline: 15 12 2021
Statut: ppublish

Résumé

This study aimed to compare 123I-FP-CIT SPECT imaging obtained from a 360° cadmium-zinc-telluride (CZT) camera with different focus configurations and from a conventional Anger camera. This prospective study (NCT03980418) included patients referred to 123I-FP-CIT SPECT imaging who consecutively underwent a 30-minute acquisition on a conventional camera immediately followed by two 15-minute acquisitions on the 360°-CZT camera with, respectively, striatum and brain focus and reconstruction parameters to give equivalent contrast ratios, albeit with higher spatial resolution for the CZT camera. Tomographic count sensitivities were calculated. The images were analyzed through visual, according to 5 independent physicians, and automatic semiquantitative analyses. Ninety-two patients were included in this study. The 360°-CZT camera tomographic count sensitivities showed increases of +25% and +18% for striatum and brain focus, respectively, as well as significantly higher quality scores (P ≤ 0.04) in comparison to the conventional camera. The κ scores of consensual visual analysis were 0.80 and 0.85, and correlation coefficients of semiquantitative analysis for striatum uptakes were 0.75 and 0.76 for the comparisons of images obtained with the 2 cameras, with striatum and brain focus, respectively, for the CZT camera. Advanced age was the single predictor of discordant cases (10/92 [11%]) showing systematically abnormal scans with the conventional camera, potentially as a result of partial volume effect. Irrespective of focus mode, this high-sensitivity 360°-CZT camera provides concordant 123I-FP-CIT SPECT results when compared with a conventional camera, but with shorter acquisition times, higher image quality, and few discordant cases possibly explained by its higher spatial resolution.

Identifiants

pubmed: 34874345
doi: 10.1097/RLU.0000000000003969
pii: 00003072-202201000-00003
doi:

Substances chimiques

CdZnTe 0
Tropanes 0
Cadmium 00BH33GNGH
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane 155797-99-2
Zinc J41CSQ7QDS
Tellurium NQA0O090ZJ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14-20

Informations de copyright

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

Conflicts of interest and sources of funding: Financial support was provided by Nancyclotep Imaging Platform. The authors declare no conflicts of interest.

Références

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Auteurs

Yuliya Piatkova (Y)

From the Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy.

Caroline Boursier (C)

From the Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy.

Manon Bordonne (M)

From the Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy.

Veronique Roch (V)

From the Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy.

Gabriela Hossu (G)

Université de Lorraine, IADI, INSERM U1254, Nancy, France.

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