Feasibility of glioblastoma tissue response mapping with physiologic BOLD imaging using precise oxygen and carbon dioxide challenge.
BOLD
Carbon dioxide
Cerebrovascular reactivity
Glioblastoma
Hypercapnia
Hyperoxia
Hypoxia
Oxygen
Journal
Magma (New York, N.Y.)
ISSN: 1352-8661
Titre abrégé: MAGMA
Pays: Germany
ID NLM: 9310752
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
29
06
2021
accepted:
19
11
2021
revised:
15
11
2021
pubmed:
8
12
2021
medline:
11
3
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
Innovative physiologic MRI development focuses on depiction of heterogenous vascular and metabolic features in glioblastoma. For this feasibility study, we employed blood oxygenation level-dependent (BOLD) MRI with standardized and precise carbon dioxide (CO Seven newly diagnosed untreated patients with suspected glioblastoma were prospectively included to undergo a BOLD study with combined CO Quantification of BOLD signal change after gas challenges can be used to identify specific responses to standardized stimuli in glioblastoma patients. Integration of this approach with automatic VOI segmentation grants improved characterization of tumor subzones and edema. Magnitude of BOLD signal change during the 3 stimuli can be visualized at voxel precision through color-coded maps overlayed onto whole brain and identified VOIs. Our preliminary investigation shows good feasibility of BOLD with standardized and precise CO
Identifiants
pubmed: 34874499
doi: 10.1007/s10334-021-00980-7
pii: 10.1007/s10334-021-00980-7
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-44Subventions
Organisme : krebsforschung schweiz
ID : KFS-3975-08-2016-R
Informations de copyright
© 2021. The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).
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