Histopathological Analysis of Cerebrovascular Lesions Associated With Aging.
Aging
Cerebrovascular disease
Dementia
Neuropathology
Journal
Journal of neuropathology and experimental neurology
ISSN: 1554-6578
Titre abrégé: J Neuropathol Exp Neurol
Pays: England
ID NLM: 2985192R
Informations de publication
Date de publication:
29 01 2022
29 01 2022
Historique:
pubmed:
8
12
2021
medline:
12
2
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
Cerebrovascular disease (CVD) has been associated with cognitive impairment. Yet, our understanding of vascular contribution to cognitive decline has been limited by heterogeneity of definitions and assessment, as well as its occurrence in cognitively healthy aging. Therefore, we aimed to establish the natural progression of CVD associated with aging. We conducted a retrospective observational study of 63 cognitively healthy participants aged 19-84 years selected through the histological archives of the CHU de Québec. Assessment of CVD lesions was performed independently by 3 observers blinded to clinical data using the Vascular Cognitive Impairment Neuropathology Guidelines (VCING). We found moderate to almost perfect interobserver agreement for most regional CVD scores. Atherosclerosis (ρ = 0.758) and arteriolosclerosis (ρ = 0.708) showed the greatest significant association with age, followed by perivascular hemosiderin deposits (ρ = 0.432) and cerebral amyloid angiopathy (CAA; ρ = 0.392). Amyloid and tau pathologies were both associated with higher CVD load, but only CAA remained significantly associated with amyloid plaques after controlling for age. Altogether, these findings support the presence of multiple CVD lesions in the brains of cognitively healthy adults, the burden of which increases with age and can be quantified in a reproducible manner using standardized histological scales such as the VCING.
Identifiants
pubmed: 34875082
pii: 6454864
doi: 10.1093/jnen/nlab125
pmc: PMC8801233
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-105Subventions
Organisme : CIHR
ID : #159778
Pays : Canada
Organisme : CIHR
ID : #406235
Pays : Canada
Informations de copyright
© 2021 American Association of Neuropathologists, Inc. All rights reserved.
Références
Histol Histopathol. 1996 Oct;11(4):1075-88
pubmed: 8930649
Brain. 2017 Feb;140(2):e12
pubmed: 28007992
Acta Neuropathol. 2010 Mar;119(3):291-302
pubmed: 19937043
J Alzheimers Dis. 2021;79(1):389-400
pubmed: 33285640
Alzheimers Dement. 2018 Feb;14(2):148-156
pubmed: 28974416
J Neuropathol Exp Neurol. 2003 Nov;62(11):1087-95
pubmed: 14656067
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
BMC Med. 2014 Nov 11;12:206
pubmed: 25385447
Acta Neuropathol. 2010 Apr;119(4):421-33
pubmed: 20204386
J Cereb Blood Flow Metab. 2017 Jan;37(1):201-216
pubmed: 26738751
Acta Neuropathol. 2021 Jan;141(1):1-24
pubmed: 33098484
Stroke. 2004 Aug;35(8):1831-5
pubmed: 15155954
Ann Neurol. 2012 Oct;72(4):599-609
pubmed: 23109154
J Neural Transm (Vienna). 2015 Apr;122(4):505-21
pubmed: 25091618
Epilepsia. 1997 Nov;38(11 Suppl):S32-4
pubmed: 19909322
Acta Neuropathol. 2005 Sep;110(3):222-31
pubmed: 16133541
Acta Neuropathol. 2010 Mar;119(3):277-90
pubmed: 20155424
Ann Neurol. 2015 Feb;77(2):251-61
pubmed: 25428654
Neurology. 2005 Mar 8;64(5):834-41
pubmed: 15753419
Lancet Neurol. 2016 Aug;15(9):934-943
pubmed: 27312738
Exp Gerontol. 2012 Nov;47(11):825-33
pubmed: 22705312
Brain. 2012 Dec;135(Pt 12):3749-56
pubmed: 23204143
J Neural Transm (Vienna). 2002 May;109(5-6):813-36
pubmed: 12111471
Lancet Neurol. 2003 Feb;2(2):89-98
pubmed: 12849265
Arch Neurol. 2003 Mar;60(3):393-8
pubmed: 12633151
Neurology. 2008 Apr 1;70(14):1208-14
pubmed: 18378884
Front Aging Neurosci. 2021 Mar 26;13:624732
pubmed: 33841126
Ann Neurol. 2011 Feb;69(2):320-7
pubmed: 21387377
Neurobiol Aging. 2009 Aug;30(8):1288-95
pubmed: 18077060
Neurology. 1999 Mar 23;52(5):991-4
pubmed: 10102418
Neurobiol Aging. 2005 Apr;26(4):491-510
pubmed: 15653178
J Neurol Sci. 1990 Aug;98(1):37-50
pubmed: 2230830
J Neurol Neurosurg Psychiatry. 1997 Dec;63(6):749-53
pubmed: 9416809
Cereb Cortex. 2006 Nov;16(11):1584-94
pubmed: 16400155
Curr Alzheimer Res. 2020;17(13):1167-1176
pubmed: 33583381
Brain. 2017 Jul 1;140(7):1829-1850
pubmed: 28334869
Stroke. 2010 Oct;41(10 Suppl):S103-6
pubmed: 20876479
J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1002-6
pubmed: 18270235
Cereb Cortex. 2004 Apr;14(4):410-23
pubmed: 15028645
Pathologe. 2005 May;26(3):201-13
pubmed: 15365765
J Neurol Sci. 2010 Dec 15;299(1-2):150-4
pubmed: 20869729
Brain. 2013 Sep;136(Pt 9):2697-706
pubmed: 23842566
Stroke. 2013 Oct;44(10):2835-41
pubmed: 23887837
Alzheimers Dement (N Y). 2021 Feb 16;7(1):e12145
pubmed: 33644295
J Neurol Sci. 2004 Nov 15;226(1-2):75-80
pubmed: 15537525
AJNR Am J Neuroradiol. 1999 Apr;20(4):637-42
pubmed: 10319975
Eur J Radiol. 2003 Mar;45(3):244-55
pubmed: 12595109
Neurology. 2005 Feb 8;64(3):494-500
pubmed: 15699381
Brain. 2016 Nov 1;139(11):2957-2969
pubmed: 27591113
Neurology. 2005 Jul 26;65(2):259-65
pubmed: 16043796
Acta Neuropathol. 2017 Aug;134(2):171-186
pubmed: 28488154
Stroke. 2006 Apr;37(4):1005-9
pubmed: 16514100
J Neuropathol Exp Neurol. 1999 Apr;58(4):376-88
pubmed: 10218633
Lancet. 1999 Sep 11;354(9182):919-20
pubmed: 10489957
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
Am J Forensic Med Pathol. 2002 Dec;23(4):307-14
pubmed: 12464802
Neuroscience. 2015 Nov 19;309:1-16
pubmed: 26241337
Neuropathol Appl Neurobiol. 2014 Apr;40(3):258-69
pubmed: 23678850
Alzheimers Dement. 2021 Jul;17(7):1121-1133
pubmed: 33663011
Neuroimage. 2020 Sep;218:116978
pubmed: 32447015
JAMA Neurol. 2021 Nov 1;78(11):1367-1374
pubmed: 34605857