DNA methylation in childhood dental caries and hypomineralization.

Child Cohort Studies DNA Methylation / genetics Dental Caries / complications Dental Enamel Hypoplasia / genetics Humans Infant, Newborn Prevalence
Dental enamel Enamel hypomineralization Epigenome Longitudinal studies Primary Tooth Twin studies

Journal

Journal of dentistry
ISSN: 1879-176X
Titre abrégé: J Dent
Pays: England
ID NLM: 0354422

Informations de publication

Date de publication:
02 2022
Historique:
received: 22 10 2021
revised: 26 11 2021
accepted: 01 12 2021
pubmed: 8 12 2021
medline: 3 3 2022
entrez: 7 12 2021
Statut: ppublish

Résumé

Epigenetic modulation of gene expression may be important in dental conditions, including dental caries and enamel hypomineralisation. The aims of this study were to assess associations between DNA methylation in cord blood leucocytes at birth, and caries experience and enamel hypomineralisation at six years of age. The study sample was from a birth cohort study of twins. Dental examinations at six years identified the presence/absence of (i) 'any caries' (untreated and treated caries), (ii) 'advanced caries' (untreated, advanced caries and/or past treatment) and (iii) hypomineralised second primary molars (HSPM). Genome-wide analysis of DNA methylation was performed on cord blood of 27 twin pairs (14 dizygotic and 13 monozygotic) using the Illumina Infinium MethylationEPIC BeadChip array. Differentially methylated CpGs (DMCpGs) and regions (DMRs) associated with each dental outcome were investigated, while accounting for the relatedness of twins. Results with a false discovery rate <0.05 were treated as statistically significant. 19 children had 'any caries', 15 had 'advanced' caries, and 18 had HSPM. No DMCpGs were associated with 'any caries', 16 and 19 DMCpGs were associated with 'advanced caries' and HSPM, respectively. DMRs were identified in association with all three outcomes. Genes implicated by these analyses included PBX1, ACAT2, LTBP3 and DDR1 which have been linked with dental tissue development in genetic studies. This exploratory study identified differential methylation in several genes at birth associated with dental caries and HSPM at six years. Further research may provide valuable insights into aetiology of dental disease and/or reveal novel molecular-based approaches for early risk stratification. Epigenetic differences at birth are likely to be associated with dental health at six years and may be valuable biomarkers of early influences on dental health.

Identifiants

DOI: 10.1016/j.jdent.2021.103913 PMID: 34875274
pubmed: 34875274
pii: S0300-5712(21)00335-3
doi: 10.1016/j.jdent.2021.103913
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103913

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE019665
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Silva Mj (S)

Inflammatory Origins, Murdoch Children's Research Institute, Melbourne, Australia; Melbourne Dental School, University of Melbourne, Melbourne, Australia; Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia. Electronic address: mihiri.silva@mcri.edu.au.

Mohandas N (M)

Epigenetics, Murdoch Children's Research Institute, Melbourne, Australia.

Craig Jm (C)

Epigenetics, Murdoch Children's Research Institute, Melbourne, Australia; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia.

Manton Dj (M)

Melbourne Dental School, University of Melbourne, Melbourne, Australia; Centrum voor Tandheelkunde en Mondzorgkunde, UMCG, University of Groningen, Groningen, The Netherlands.

Saffery R (S)

Epigenetics, Murdoch Children's Research Institute, Melbourne, Australia.

Southey Mc (S)

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia; Department of Clinical Pathology, University of Melbourne, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.

Burgner Dp (B)

Inflammatory Origins, Murdoch Children's Research Institute, Melbourne, Australia; Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Clayton, Australia.

Lucas J (L)

Melbourne Dental School, University of Melbourne, Melbourne, Australia.

Kilpatrick Nm (K)

Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Facial Sciences, Murdoch Children's Research Institute, Melbourne, Australia.

Hopper Jl (H)

Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Scurrah Kj (S)

Facial Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Li S (L)

Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies des dents › Déminéralisation dentaire › Caries dentaires › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système stomatognathique › Malformations dentaires › Anomalies de développement de l'émail › Hypoplasie de l'émail dentaire › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › DNA methylation in childhood dental caries and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › DNA methylation in childhood dental caries and...