Protective effect of green tea and epigallocatechin-3-gallate in a LPS-induced systemic inflammation model.
Epigallocatechin-3-gallate
Green tea
Inflammation
Macrophages
T regulatory lymphocytes, neutrophils and MDSCs
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
12
03
2021
revised:
29
09
2021
accepted:
12
11
2021
pubmed:
8
12
2021
medline:
8
3
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
Inflammation causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation damage. Polyphenol compounds found in green tea (GTE), including the most important component epigallocatechin-3-gallate (EGCG), have a great therapeutic potential. Here, protective properties of GTE and EGCG against lipopolysaccharide (LPS)-induced inflammation are explored. To this end, the effects of GTE and EGCG were studied on LPS challenged macrophages. Mice received GTE (250 mg/kg/d/p.o) or EGCG (25 mg/kg/d/i.p.) for 7 d, before the inflammation shock was provoked with a single intraperitoneal injection of LPS. The frequencies of lymphocytes CD4
Identifiants
pubmed: 34875388
pii: S0955-2863(21)00340-5
doi: 10.1016/j.jnutbio.2021.108920
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
Protective Agents
0
Tea
0
Catechin
8R1V1STN48
epigallocatechin gallate
BQM438CTEL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108920Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.