Taste Bud Connectome: Implications for Taste Information Processing.
CALHM1
electron microscopy
labeled line
nerve fibers
synapse
taste buds
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
02 02 2022
02 02 2022
Historique:
received:
29
03
2021
revised:
24
11
2021
accepted:
01
12
2021
pubmed:
9
12
2021
medline:
16
2
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
Taste buds contain multiple cell types, two of which mediate transduction of specific taste qualities: Type III cells transduce sour while Type II cells transduce either sweet, or bitter or umami. In order to discern the degree of interaction between different cell types and specificity of connectivity with the afferent nerve fibers (NFs), we employed serial blockface scanning electron microscopy (sbfSEM) through five circumvallate mouse taste buds. Points of contact between Type II and Type III cells are rare and lack morphologically identifiable synapses, suggesting that interaction between these cell types does not occur via synapses. Of the 127 NFs that make synaptic contacts with taste cells in the sampling volume, ∼70% (
Identifiants
pubmed: 34876471
pii: JNEUROSCI.0838-21.2021
doi: 10.1523/JNEUROSCI.0838-21.2021
pmc: PMC8808728
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
804-816Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC012555
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014728
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017679
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC013186
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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