Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions.
Dysbiosis
Gut microbiota
Inflammation
Inflammatory bowel disease
Intestinal barrier
Quorum sensing
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Nov 2021
14 Nov 2021
Historique:
received:
16
03
2021
revised:
17
08
2021
accepted:
27
10
2021
entrez:
8
12
2021
pubmed:
9
12
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome. This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem. This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem. We will also provide clues on the role of QS molecules that may exert, directly or indirectly through their bacterial gossip, an influence on intestinal epithelial barrier function, intestinal inflammation, and intestinal carcinogenesis. This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player. Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.
Identifiants
pubmed: 34876787
doi: 10.3748/wjg.v27.i42.7247
pmc: PMC8611211
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7247-7270Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Seksik P reports consulting fees from Abbvie, Takeda, Merck-MSD, Pfizer, Astellas, Janssen and Biocodex and grants from Biocodex and Janssen. These COIs are unrelated to the current presentation. All other authors declare no conflict of interests for this article.
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