A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.
Immunology
Obesity medicine
Surgery
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
14
07
2021
revised:
22
10
2021
accepted:
04
11
2021
entrez:
8
12
2021
pubmed:
9
12
2021
medline:
9
12
2021
Statut:
epublish
Résumé
The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome.
Identifiants
pubmed: 34877488
doi: 10.1016/j.isci.2021.103421
pii: S2589-0042(21)01392-4
pmc: PMC8633018
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103421Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Adv Nutr. 2018 Jan 1;9(1):21-29
pubmed: 29438462
Lab Anim. 2021 Jun;55(3):233-243
pubmed: 33215575
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Cell Mol Immunol. 2020 Aug;17(8):884-886
pubmed: 32346101
Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1076-84
pubmed: 22932782
Antioxid Redox Signal. 2011 Jan 15;14(2):261-73
pubmed: 20524846
Biogerontology. 2012 Apr;13(2):147-55
pubmed: 22057901
Obesity (Silver Spring). 2017 Nov;25(11):1921-1931
pubmed: 28921894
J Med Primatol. 2012 Apr;41(2):89-106
pubmed: 22150842
Diabetes. 2017 Feb;66(2):392-406
pubmed: 28108608
Immunology. 2018 Dec;155(4):407-417
pubmed: 30229891
Drugs. 2013 Jun;73(9):989-97
pubmed: 23740412
Sci Technol Human Values. 2018 Jul;43(4):622-648
pubmed: 30008492
Biol Mood Anxiety Disord. 2011 Nov 07;1(1):9
pubmed: 22738250
Nat Med. 2009 Aug;15(8):930-9
pubmed: 19633656
Semin Immunopathol. 2019 Jul;41(4):461-475
pubmed: 31025085
Ann N Y Acad Sci. 2017 Mar;1391(1):85-100
pubmed: 27723940
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8878-83
pubmed: 9238071
Lancet. 2018 Aug 25;392(10148):637-649
pubmed: 30122305
Sci Rep. 2015 Nov 19;5:16801
pubmed: 26582486
JAMA. 2013 Dec 11;310(22):2401-2
pubmed: 24189645
Br J Pharmacol. 2011 Oct;164(4):1248-62
pubmed: 21265828
N Engl J Med. 2020 Oct 15;383(16):1535-1543
pubmed: 33053284
N Engl J Med. 2014 May 22;370(21):2002-13
pubmed: 24679060
Obes Surg. 2019 Jan;29(1):99-108
pubmed: 30229460
Annu Rev Immunol. 2016 May 20;34:609-33
pubmed: 27168246
Gerontology. 2016;62(6):611-617
pubmed: 27120471
Cell Metab. 2007 Aug;6(2):137-43
pubmed: 17681149
mSystems. 2018 Nov 13;3(6):
pubmed: 30443602
Int Immunol. 2001 Apr;13(4):593-600
pubmed: 11282998
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
Obes Surg. 2010 Sep;20(9):1293-305
pubmed: 20383602
Curr Obes Rep. 2017 Sep;6(3):253-265
pubmed: 28780756
J Lipid Res. 2020 Apr;61(4):480-491
pubmed: 32086245
Metabolism. 2015 Jan;64(1):131-45
pubmed: 25497344
ILAR J. 2006;47(3):259-71
pubmed: 16804200
Obes Surg. 2019 Dec;29(12):4084-4094
pubmed: 31630327
J Lipid Res. 2008 Jul;49(7):1562-8
pubmed: 18390487
Gastroenterology. 2019 Mar;156(4):1041-1051.e4
pubmed: 30445014
J Lipid Res. 2005 Nov;46(11):2347-55
pubmed: 16150820
Methods Mol Biol. 2001;155:21-51
pubmed: 11293073
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
J Exp Med. 2018 Nov 5;215(11):2796-2814
pubmed: 30355617
Int J Mol Sci. 2019 May 13;20(9):
pubmed: 31085992
Cell Metab. 2016 Jul 12;24(1):63-74
pubmed: 27411009
N Engl J Med. 2020 Dec 3;383(23):2197-2200
pubmed: 33264824
Ann N Y Acad Sci. 2018 Jan;1411(1):53-64
pubmed: 28868615
J Exp Med. 2004 Feb 2;199(3):303-13
pubmed: 14757740
Benef Microbes. 2018 Apr 25;9(3):367-373
pubmed: 29482339
Nutrients. 2017 Dec 12;9(12):
pubmed: 29231905
Curr Obes Rep. 2019 Sep;8(3):317-332
pubmed: 31175629
JAMA. 2013 Jun 5;309(21):2240-9
pubmed: 23736733
JAMA. 2018 Jan 16;319(3):279-290
pubmed: 29340677
Cleve Clin J Med. 2017 Dec;84(12):951-958
pubmed: 29244650
Blood. 2009 Feb 26;113(9):2119-20; author reply 2120
pubmed: 19246567
Biopharm Drug Dispos. 1995 Jul;16(5):351-80
pubmed: 8527686
Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):341-6
pubmed: 21587064
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E424-32
pubmed: 24368666
Mol Cell Endocrinol. 2019 Mar 1;483:1-10
pubmed: 30543876
JAMA. 2018 Jan 16;319(3):235-237
pubmed: 29340659
Lancet. 2015 Sep 5;386(9997):964-73
pubmed: 26369473
Nutrients. 2020 May 19;12(5):
pubmed: 32438689
Lab Anim (NY). 2005 May;34(5):31-6
pubmed: 15861156
Obes Surg. 2017 Nov;27(11):2933-2939
pubmed: 28534189
J Cell Physiol. 2018 Sep;233(9):6425-6440
pubmed: 29319160
Nature. 2012 Jun 28;486(7404):549-53
pubmed: 22722857
Sci Rep. 2021 Jan 27;11(1):2340
pubmed: 33504894
J Med Primatol. 2009 Jun;38(3):204-12
pubmed: 19220683
Obes Surg. 2019 Mar;29(3):782-795
pubmed: 30421326
Ann Intern Med. 2018 Dec 4;169(11):741-750
pubmed: 30383139
Mol Metab. 2017 Feb 16;6(4):317-326
pubmed: 28377871
Nat Rev Endocrinol. 2018 Mar;14(3):140-162
pubmed: 29348476
Can J Diabetes. 2017 Aug;41(4):401-406
pubmed: 28457649
Nat Methods. 2015 Oct;12(10):902-3
pubmed: 26418763
N Engl J Med. 2013 Jul 11;369(2):145-54
pubmed: 23796131
Nature. 2020 Nov;587(7834):448-454
pubmed: 33149306
J Immunol. 1999 Dec 1;163(11):5920-8
pubmed: 10570278
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5
pubmed: 16033867
JAMA. 2016 Jun 14;315(22):2424-34
pubmed: 27299618
Obesity (Silver Spring). 2015 Dec;23(12):2323
pubmed: 26524609
Gut. 2018 Jul;67(7):1203-1204
pubmed: 29382775
J Biol Chem. 2015 May 22;290(21):13250-62
pubmed: 25869128
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27
pubmed: 29222373
Nature. 2019 Dec;576(7785):143-148
pubmed: 31776512
Am J Physiol. 1967 Apr;212(4):777-82
pubmed: 6024438
Mol Aspects Med. 2017 Aug;56:75-89
pubmed: 28390813
Sci Rep. 2019 Oct 31;9(1):15762
pubmed: 31673032
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
Eur J Pharmacol. 2015 Jul 15;759:221-30
pubmed: 25814249
Psychopharmacology (Berl). 1984;83(1):1-16
pubmed: 6429692
Diabetes Care. 2016 Jun;39(6):893-901
pubmed: 27222547
Science. 2013 Aug 23;341(6148):856-8
pubmed: 23970691
Cell Metab. 2013 Jun 4;17(6):851-859
pubmed: 23747244
Obesity (Silver Spring). 2014 Jun;22(6):1430-8
pubmed: 24715424
Obes Surg. 2014 Aug;24(8):1126-35
pubmed: 25008469
JAMA. 2021 Jul 13;326(2):129-130
pubmed: 34160571
PLoS One. 2016 Apr 27;11(4):e0154253
pubmed: 27119555
Diabetes. 2020 May;69(5):823-829
pubmed: 32312898
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Int J Obes. 1985;9(3):213-24
pubmed: 3902688
Eur J Immunol. 2017 Nov;47(11):1867-1874
pubmed: 28849586
Diabetes Care. 2018 Jan;41(Suppl 1):S38-S50
pubmed: 29222375
Curr Diab Rep. 2019 Dec 4;19(12):156
pubmed: 31802258
Surg Obes Relat Dis. 2019 Jul;15(7):1146-1152
pubmed: 31202681
J Clin Invest. 2011 Jun;121(6):2111-7
pubmed: 21633179
J Diabetes. 2017 Jul;9(7):656-666
pubmed: 28093902