STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
Cell biology
Immunology
Molecular biology
Neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
23
02
2021
revised:
29
07
2021
accepted:
10
11
2021
entrez:
8
12
2021
pubmed:
9
12
2021
medline:
9
12
2021
Statut:
epublish
Résumé
Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimulator of interferon genes (STING) sense foreign and self-DNA and trigger type I interferon (IFN) immune responses. We demonstrate here that following PNI, the cGAS/STING pathway is upregulated in the sciatic nerve of naive rats and dysregulated in old rats. In a nerve crush mouse model where STING is knocked out, myelin content in sciatic nerve is increased resulting in accelerated functional axon recovery. STING KO mice have lower macrophage number in sciatic nerve and decreased microglia activation in spinal cord 1 week post injury. STING activation regulated processing of colony stimulating factor 1 receptor (CSF1R) and microglia survival
Identifiants
pubmed: 34877494
doi: 10.1016/j.isci.2021.103434
pii: S2589-0042(21)01405-X
pmc: PMC8633968
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103434Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
All authors are employees and some are shareholders of Novartis.
Références
Neuroscience. 1990;39(1):151-70
pubmed: 2089275
Brain. 2012 Jan;135(Pt 1):88-104
pubmed: 22094537
Acta Neuropathol. 2015 Nov;130(5):605-18
pubmed: 26419777
PLoS One. 2015 Jul 27;10(7):e0127336
pubmed: 26214311
Aging Cell. 2014 Feb;13(1):60-9
pubmed: 23953759
Mol Pain. 2018 Jan-Dec;14:1744806918764979
pubmed: 29546785
Front Cell Neurosci. 2018 Jul 24;12:215
pubmed: 30087595
Acta Neuropathol Commun. 2018 Feb 15;6(1):9
pubmed: 29448957
Aging Cell. 2018 Dec;17(6):e12833
pubmed: 30168637
Nature. 2006 Jul 6;442(7098):39-44
pubmed: 16823444
Nat Rev Neurosci. 2018 Mar;19(3):138-152
pubmed: 29416128
Cell. 2020 Oct 29;183(3):636-649.e18
pubmed: 33031745
J Immunol. 2017 Nov 1;199(9):3222-3233
pubmed: 28939760
Cell. 2015 Aug 27;162(5):1127-39
pubmed: 26279190
Nat Rev Genet. 2010 Oct;11(10):710-22
pubmed: 20838411
Cell Death Differ. 2020 Nov;27(11):2989-3003
pubmed: 32948836
J Vis Exp. 2015 Sep 25;(103):
pubmed: 26436455
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Cell Rep. 2019 Nov 5;29(6):1539-1554.e7
pubmed: 31693894
Nucleic Acids Res. 2016 Sep 19;44(16):e132
pubmed: 27302131
Mol Cell Biol. 2004 Jan;24(1):454-64
pubmed: 14673177
Adv Drug Deliv Rev. 2015 Mar;82-83:160-7
pubmed: 25446133
Cell. 2000 Feb 18;100(4):391-8
pubmed: 10693756
Adv Exp Med Biol. 2002;513:87-113
pubmed: 12575818
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nat Commun. 2020 May 21;11(1):2552
pubmed: 32439942
J Comp Neurol. 1997 Sep 29;386(3):461-76
pubmed: 9303429
J Immunol. 1992 Oct 15;149(8):2656-61
pubmed: 1401905
Neural Regen Res. 2019 Aug;14(8):1335-1342
pubmed: 30964051
Genome Biol. 2010;11(3):R25
pubmed: 20196867
Prog Neurobiol. 2001 Jun;64(2):109-27
pubmed: 11240209
Neuron. 2012 Aug 23;75(4):633-47
pubmed: 22920255
Shock. 2010 Jul;34(1):55-9
pubmed: 19997055
J Neuroinflammation. 2011 Aug 30;8:110
pubmed: 21878126
Glia. 2008 Nov 1;56(14):1566-77
pubmed: 18803324
Mol Cell Biol. 2013 Jan;33(2):194-212
pubmed: 23109432
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
Int J Biol Sci. 2020 Jan 1;16(1):116-134
pubmed: 31892850
Brain Behav Immun. 2010 Nov;24(8):1254-67
pubmed: 20688153
Stem Cell Reports. 2017 Feb 14;8(2):334-345
pubmed: 28111278
Brain Res Bull. 1994;34(1):73-8
pubmed: 8193937
Hand (N Y). 2015 Jun;10(2):161-7
pubmed: 26034424
Prog Neurobiol. 2019 Feb;173:102-121
pubmed: 30579784
J Clin Invest. 2011 Nov;121(11):4332-47
pubmed: 21965333
Sci Signal. 2012 Mar 06;5(214):ra20
pubmed: 22394562
Glia. 2002 Nov;40(2):195-205
pubmed: 12379907
Sci Rep. 2019 Sep 18;9(1):13508
pubmed: 31534149
Nat Neurosci. 2016 Jan;19(1):94-101
pubmed: 26642091
J Leukoc Biol. 1989 Dec;46(6):556-64
pubmed: 2572659
Infect Immun. 1996 Aug;64(8):2897-903
pubmed: 8757810
Br J Pharmacol. 2009 Oct;158(3):638-51
pubmed: 19764983
J Immunol. 1998 May 1;160(9):4587-95
pubmed: 9574566
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
Exp Neurol. 1994 Jun;127(2):284-90
pubmed: 8033968
Exp Neurol. 2006 Nov;202(1):161-6
pubmed: 16828744
Prog Mol Biol Transl Sci. 2015;131:251-79
pubmed: 25744676
Exp Neurol. 2014 Aug;258:5-16
pubmed: 25017883
Aging Cell. 2011 Apr;10(2):263-76
pubmed: 21108733
Lab Invest. 2003 Feb;83(2):175-85
pubmed: 12594233
Nature. 2010 Mar 4;464(7285):104-7
pubmed: 20203610
Nucleic Acids Res. 2012 Sep 1;40(17):e133
pubmed: 22638577