Airway remodeling in horses with mild and moderate asthma.
central airway
endobronchial biopsy
histomorphometry
semiquantitative histologic score
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
revised:
20
11
2021
received:
31
08
2020
accepted:
22
11
2021
pubmed:
9
12
2021
medline:
27
1
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
There is a remodeling of the central airways in horses with severe asthma but whether a similar process occurs in horses with the mild or moderate asthma (MMA) is unknown. To evaluate lesions affecting the central airways of horses with MMA. Twelve horses with MMA and 8 control horses. Case-control retrospective study of horses classified as MMA affected or controls based on history and bronchoalveolar lavage fluid cytology. Endobronchial biopsies were analyzed using histomorphometry and a semiquantitative histologic scoring system. Histomorphometry identified epithelial hyperplasia (47 μm Tissue remodeling of the bronchial lamina propria, epithelium, and smooth muscle was present in horses with MMA.
Sections du résumé
BACKGROUND
BACKGROUND
There is a remodeling of the central airways in horses with severe asthma but whether a similar process occurs in horses with the mild or moderate asthma (MMA) is unknown.
OBJECTIVES
OBJECTIVE
To evaluate lesions affecting the central airways of horses with MMA.
ANIMALS
METHODS
Twelve horses with MMA and 8 control horses.
METHODS
METHODS
Case-control retrospective study of horses classified as MMA affected or controls based on history and bronchoalveolar lavage fluid cytology. Endobronchial biopsies were analyzed using histomorphometry and a semiquantitative histologic scoring system.
RESULTS
RESULTS
Histomorphometry identified epithelial hyperplasia (47 μm
CONCLUSIONS AND CLINICAL RELEVANCE
CONCLUSIONS
Tissue remodeling of the bronchial lamina propria, epithelium, and smooth muscle was present in horses with MMA.
Identifiants
pubmed: 34877706
doi: 10.1111/jvim.16333
pmc: PMC8783337
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-291Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2015-04092
Informations de copyright
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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