A Point Mutation in the Human Parainfluenza Virus Type 2 Nucleoprotein Leads to Two Separate Effects on Virus Replication.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
23 02 2022
Historique:
pubmed: 9 12 2021
medline: 5 3 2022
entrez: 8 12 2021
Statut: ppublish

Résumé

Paramyxovirus genomes, like that of human parainfluenza virus type 2 (hPIV2), have lengths of precisely multiples-of-six nucleotides ("rule of six"), where each nucleoprotein subunit (NP) binds exactly six nucleotides. Ten residues of its RNA binding groove contact the genome RNA; but only one, Q202, directly contacts a nucleotide base. The mutation of NP

Identifiants

pubmed: 34878809
doi: 10.1128/JVI.02067-21
pmc: PMC8865444
doi:

Substances chimiques

Nucleocapsid Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0206721

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Auteurs

Naoki Saka (N)

Department of Microbiology, School of Medicine, Wakayama Medical Universitygrid.412857.d, Wakayama, Japan.

Yusuke Matsumoto (Y)

Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Keisuke Ohta (K)

Department of Microbiology, School of Medicine, Wakayama Medical Universitygrid.412857.d, Wakayama, Japan.

Daniel Kolakofsky (D)

Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, Geneva, Switzerland.

Machiko Nishio (M)

Department of Microbiology, School of Medicine, Wakayama Medical Universitygrid.412857.d, Wakayama, Japan.

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Classifications MeSH