Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/

Animals Disease Models, Animal Infarction, Middle Cerebral Artery / pathology Ischemic Stroke Mice Neovascularization, Pathologic / pathology Oligodendrocyte Precursor Cells / metabolism Oligodendroglia / metabolism Remyelination White Matter / pathology beta Catenin
Angiogenesis Wnt/β-catenin ischemia oligodendrocyte precursor cells white matter

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
05 2022
Historique:
pubmed: 9 12 2021
medline: 14 4 2022
entrez: 8 12 2021
Statut: ppublish

Résumé

White matter injury is a critical pathological characteristic during ischemic stroke. Oligodendrocyte precursor cells participate in white matter repairing and remodeling during ischemic brain injury. Since oligodendrocyte precursor cells could promote Wnt-dependent angiogenesis and migrate along vasculature for the myelination during the development in the central nervous system, we explore whether exogenous oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination after middle cerebral artery occlusion in mice. Here, oligodendrocyte precursor cell transplantation improved motor and cognitive function, and alleviated brain atrophy. Furthermore, oligodendrocyte precursor cell transplantation promoted functional angiogenesis, and increased myelin basic protein expression after ischemic stroke. The further study suggested that white matter repairing after oligodendrocyte precursor cell transplantation depended on angiogenesis induced by Wnt/β-catenin signal pathway. Our results demonstrated a novel pathway that Wnt7a from oligodendrocyte precursor cells acting on endothelial β-catenin promoted angiogenesis and improved neurobehavioral outcomes, which facilitated white matter repair and remodeling during ischemic stroke.

Identifiants

DOI: 10.1177/0271678X211065391 PMID: 34878958 PMC: PMC9254032
pubmed: 34878958
doi: 10.1177/0271678X211065391
pmc: PMC9254032
doi:

Substances chimiques

beta Catenin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

757-770

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Auteurs

Li-Ping Wang (LP)

Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China.
Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Jiaji Pan (J)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Yongfang Li (Y)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Jieli Geng (J)

Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China.

Chang Liu (C)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Lin-Yuan Zhang (LY)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Panting Zhou (P)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Yao-Hui Tang (YH)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Yongting Wang (Y)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Zhijun Zhang (Z)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Guo-Yuan Yang (GY)

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › Infarctus du territoire de l'artère cérébrale moyenne › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Précurseurs des oligodendrocytes › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Remyélinisation › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Oligodendrocyte precursor cell transplantation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Oligodendrocyte precursor cell transplantation...