Antiproliferative activity of two copper (II) complexes on colorectal cancer cell models: Impact on ROS production, apoptosis induction and NF-κB inhibition.

Apoptosis Caco-2 Cells Colorectal Neoplasms / drug therapy Copper Humans NF-kappa B Reactive Oxygen Species
Antiproliferative activity Apoptosis Copper complexes MMP-9 expression inhibition NF-κB pathway inhibition ROS production

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Feb 2022
Historique:
received: 27 09 2021
revised: 29 11 2021
accepted: 01 12 2021
pubmed: 9 12 2021
medline: 27 1 2022
entrez: 8 12 2021
Statut: ppublish

Résumé

The main goal of this work was to screen the antiproliferative activity and mechanism of actions of two copper complexes: [Cu(dmp)

Identifiants

DOI: 10.1016/j.ejps.2021.106092 PMID: 34879254
pubmed: 34879254
pii: S0928-0987(21)00393-6
doi: 10.1016/j.ejps.2021.106092
pii:
doi:

Substances chimiques

NF-kappa B 0
Reactive Oxygen Species 0
Copper 789U1901C5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106092

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Maria C Ruiz (MC)

Centro de Química Inorgánica (CEQUINOR, CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv 120 1465, La Plata 1900, Argentina.

Karen Perelmulter (K)

Cell Biology Unit, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.

Pedro Levín (P)

Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile. Alameda 3363, Estación Central, Santiago Chile.

Adolfo I B Romo (AIB)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.

Luis Lemus (L)

Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile. Alameda 3363, Estación Central, Santiago Chile.

Mariela Bollati -Fogolín (MB)

Cell Biology Unit, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.

Ignacio E León (IE)

Centro de Química Inorgánica (CEQUINOR, CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv 120 1465, La Plata 1900, Argentina. Electronic address: ileon@biol.unlp.edu.ar.

Ana Laura Di Virgilio (AL)

Centro de Química Inorgánica (CEQUINOR, CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv 120 1465, La Plata 1900, Argentina. Electronic address: aldivirgilio@biol.unlp.edu.ar.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Antiproliferative activity of two copper (II)...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Antiproliferative activity of two copper (II)...