Cognitive reserve proxies, Alzheimer pathologies, and cognition.
Alzheimer pathology
Cognitive activity
Cognitive reserve
Education
Intelligence
Occupation
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
02
03
2021
revised:
09
10
2021
accepted:
10
10
2021
pubmed:
9
12
2021
medline:
15
2
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
This study aimed to explore the moderating effects of the frequently used cognitive reserve (CR) proxies [i.e., education, premorbid intelligence quotient (pIQ), occupational complexity (OC), and lifetime cognitive activity (LCA)] on the relationships between various in vivo Alzheimer's disease (AD) pathologies and cognition. In total, 351 [268 cognitively unimpaired (CU), 83 cognitive impaired (CI)] older adults underwent multi-modal brain imaging to measure AD pathologies and cognitive assessments, and information on CR proxies was obtained. For overall participants, only education moderated the relationship between Aβ deposition and cognition. Education, pIQ, and LCA, but not OC, showed moderating effect on the relationship between AD-signature cerebral hypometabolism and cognition. In contrast, only OC had a moderating effect on the relationship between cortical atrophy of the AD-signature regions and cognition. Such moderation effects of the CR proxies were similarly observed in CI individuals, but most of them were not in CU individuals. The findings suggest that the proposed CR proxies have different moderating effects on the relationships between specific AD pathologies and cognition.
Identifiants
pubmed: 34879329
pii: S0197-4580(21)00318-3
doi: 10.1016/j.neurobiolaging.2021.10.005
pmc: PMC9234822
mid: NIHMS1810534
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-95Subventions
Organisme : NIA NIH HHS
ID : U01 AG072177
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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