The Alzheimer's Disease Amyloid Precursor Protein and its Neuritogenic Actions.
Amyloid precursor protein
RhoA
function
miRNA.
neurite
neurogenesis
synaptogenesis
Journal
Current Alzheimer research
ISSN: 1875-5828
Titre abrégé: Curr Alzheimer Res
Pays: United Arab Emirates
ID NLM: 101208441
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
06
2020
revised:
09
05
2021
accepted:
14
06
2021
pubmed:
10
12
2021
medline:
2
4
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer's disease as the source of the amyloid β peptide; however, its physiological actions within the nervous system are also important as it is involved in a range of neuronal activities, including neurogenesis, synaptic plasticity, neurite outgrowth, and neuroprotection. Of the different neuronal functions that APP can affect, some may be relevant to APP's role in Alzheimer's disease, while others can be primarily related to its physiological roles. This review will focus on APP's neuritogenic actions and surmise the key molecular mechanisms, as well as the structural and signaling requirements, which form the basis for APP's neuritogenic effects. Deciphering the normal function(s) of APP is valuable to properly understanding its role in health as well as Alzheimer's disease.
Identifiants
pubmed: 34879801
pii: CAR-EPUB-119297
doi: 10.2174/1567205018666211208141017
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
772-786Informations de copyright
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