Reduced Regional Cerebral Blood Flow Measured by

DI5-CUFFS HMPAO dry immersion microgravity regional cerebral blood flow thigh cuffs

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2021
Historique:
received: 04 10 2021
accepted: 28 10 2021
entrez: 9 12 2021
pubmed: 10 12 2021
medline: 10 12 2021
Statut: epublish

Résumé

Microgravity induces a cephalad fluid shift that is responsible for cephalic venous stasis that may increase intracranial pressure (ICP) in astronauts. However, the effects of microgravity on regional cerebral blood flow (rCBF) are not known. We therefore investigated changes in rCBF in a 5-day dry immersion (DI) model. Moreover, we tested thigh cuffs as a countermeasure to prevent potential microgravity-induced modifications in rCBF. Around 18 healthy male participants underwent 5-day DI with or without a thigh cuffs countermeasure. They were randomly allocated to a control (

Identifiants

pubmed: 34880784
doi: 10.3389/fphys.2021.789298
pmc: PMC8645987
doi:

Types de publication

Journal Article

Langues

eng

Pagination

789298

Informations de copyright

Copyright © 2021 Guillon, Kermorgant, Charvolin, Bonneville, Bareille, Cassol, Beck, Beaurain, Péran, Lotterie, Pavy-Le Traon and Payoux.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Laurent Guillon (L)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.

Marc Kermorgant (M)

INSERM UMR 1297, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse University Hospital, Toulouse, France.

Thomas Charvolin (T)

Department of Neuroradiology, Toulouse University Hospital, Toulouse, France.

Fabrice Bonneville (F)

Department of Neuroradiology, Toulouse University Hospital, Toulouse, France.
INSERM URM 1214, Toulouse NeuroImaging Center (ToNIC), Toulouse University Hospital, Toulouse, France.

Marie-Pierre Bareille (MP)

Institute for Space Medicine and Physiology (MEDES), Toulouse, France.

Emmanuelle Cassol (E)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.

Arnaud Beck (A)

Institute for Space Medicine and Physiology (MEDES), Toulouse, France.

Marie Beaurain (M)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.

Patrice Péran (P)

INSERM URM 1214, Toulouse NeuroImaging Center (ToNIC), Toulouse University Hospital, Toulouse, France.

Jean-Albert Lotterie (JA)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
INSERM URM 1214, Toulouse NeuroImaging Center (ToNIC), Toulouse University Hospital, Toulouse, France.

Anne Pavy-Le Traon (AP)

INSERM UMR 1297, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse University Hospital, Toulouse, France.
Department of Neurology, Toulouse University Hospital, Toulouse, France.

Pierre Payoux (P)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
INSERM URM 1214, Toulouse NeuroImaging Center (ToNIC), Toulouse University Hospital, Toulouse, France.

Classifications MeSH