Glutathione Transferases as Efficient Ketosteroid Isomerases.
alternative functions
androstenedione
ecdysteroid
enzyme evolution
glutathione
ketosteroid isomerase
progesterone
steroid hormone
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
08
2021
accepted:
01
11
2021
entrez:
9
12
2021
pubmed:
10
12
2021
medline:
10
12
2021
Statut:
epublish
Résumé
In addition to their well-established role in detoxication, glutathione transferases (GSTs) have other biological functions. We are focusing on the ketosteroid isomerase activity, which appears to contribute to steroid hormone biosynthesis in mammalian tissues. A highly efficient GST A3-3 is present in some, but not all, mammals. The alpha class enzyme GST A3-3 in humans and the horse shows the highest catalytic efficiency with k
Identifiants
pubmed: 34881290
doi: 10.3389/fmolb.2021.765970
pii: 765970
pmc: PMC8645602
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
765970Informations de copyright
Copyright © 2021 Mannervik, Ismail, Lindström, Sjödin and Ing.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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