Effect of hyperoxia and hypoxia on retinal vascular parameters assessed with optical coherence tomography angiography.
healthy subjects
hyperoxia
hypoxia
optical coherence tomography angiography
retinal blood vessel diameter
retinal oxygen saturation
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
20
10
2021
received:
03
08
2021
accepted:
29
11
2021
pubmed:
10
12
2021
medline:
12
8
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
To investigate the response of the superficial and deep capillary plexuses to hyperoxia and hypoxia using optical coherence tomography angiography (OCT-A) and retinal vessel analyzer. Twenty-four healthy volunteers participated in this randomized, double-masked, cross-over study. For each subject, two study days were scheduled: on one study day, hyperoxia was induced by breathing 100% oxygen whereas on the other study day, hypoxia was induced by breathing a mixture of 88% nitrogen and 12% oxygen. Perfusion density was calculated in the superficial vascular plexus (SVP) and the deep capillary plexus (DCP), using OCT-A before (normal breathing) and during breathing of the gas mixtures. Retinal vessel calibres in major retinal vessels were measured using a dynamic vessel analyzer. During 100% oxygen breathing, a significant decrease in DCP perfusion density from 41.7 ± 2.4 a.u to 35.6 ± 3.1 a.u. (p < 0.001) was observed, which was accompanied by a significant decrease in vessel diameters in major retinal arteries and veins (p < 0.001 each). No significant change in perfusion density in the SVP occurred (p = 0.33). In contrast, during hypoxia, perfusion density in the SVP significantly increased from 34.4 ± 3.0 a.u. to 37.1 ± 2.2 a.u. (p < 0.001), while it remained stable in the DCP (p = 0.25). A significant increase in retinal vessel diameters was found (p < 0.01). Systemic oxygen saturation correlated negatively with perfusion density in the SVP and the DCP and retinal vessel diameters (p < 0.005 each). Our results show that systemic hyperoxia induces a significant decrease in vessel density in the DCP, while hypoxia leads to increased vessel density limited to the SVP. These results indicate that the retinal circulation shows the ability to adapt its blood flow to metabolic changes with high local resolution dependent on the capillary plexus.
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1272-e1279Subventions
Organisme : Nanyang Technological University
Organisme : SERI-Lee Foundation
ID : LF1019-1
Organisme : National Medical Research Council
ID : TA/MOH-000249-00/2018
Organisme : National Medical Research Council
ID : OFLCG/004c/2018
Organisme : Austrian Science Fund
ID : KLI721
Organisme : Duke-NUS Medical School
ID : Duke-NUS-KP(Coll)/2018/0009A
Organisme : National Research Foundation Singapore
ID : A20H4b0141
Organisme : Austrian Science Fund FWF
ID : KLI 721
Pays : Austria
Organisme : Singapore Eye Research Institute
Organisme : National Medical Research Council
ID : OFIRG/0048/2017
Organisme : National Medical Research Council
ID : CG/C010A/2017
Informations de copyright
© 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
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