Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy.
4D flow MRI
Aortic hemodynamics
Aortic relative pressure
Aortic stiffness
Dilated cardiomyopathy
Journal
Journal of cardiovascular translational research
ISSN: 1937-5395
Titre abrégé: J Cardiovasc Transl Res
Pays: United States
ID NLM: 101468585
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
02
08
2021
accepted:
20
10
2021
pubmed:
10
12
2021
medline:
3
11
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol.
Identifiants
pubmed: 34882286
doi: 10.1007/s12265-021-10181-1
pii: 10.1007/s12265-021-10181-1
pmc: PMC9622552
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
692-707Subventions
Organisme : British Heart Foundation
ID : PG/15/104/31913
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 088641/Z/09/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209450/Z/17/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : TG/17/3/33406
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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