Systematic assessment of the humoral response against SARS-CoV-2 in a French cohort of 283 patients with rheumatic diseases.
COVID-19
DMARDs
Rheumatoid arthritis
Serology
Spondyloarthritis
Journal
Joint bone spine
ISSN: 1778-7254
Titre abrégé: Joint Bone Spine
Pays: France
ID NLM: 100938016
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
23
07
2021
revised:
15
11
2021
accepted:
22
11
2021
pubmed:
10
12
2021
medline:
14
5
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
To estimate the seroprevalence of SARS-CoV-2 infection in patients with rheumatic diseases and to specify the proportion of asymptomatic and symptomatic forms of COVID-19. We screened for SARS-CoV-2 infection among spondyloarthritis (SpA, n=143) or rheumatoid arthritis (RA, n=140) patients in our outpatient clinic at Cochin Hospital in Paris between June and August 2020. We performed a qualitative SARS-CoV-2 serological test which detects IgG directed against the N nucleocapsid protein (anti-N) and, for some patients, against the Spike protein (anti-S). Descriptive analyses were managed. During June-August 2020, the SARS-CoV-2 seroprevalence rate in our population was 2.83% (8/283 patients) without significant difference between RA and SpA patients (2.14% and 3.5%, respectively). We report 11 out of 283 patients (3.8%) with a diagnosis of SARS-CoV-2 infection. Among these 11 patients, 1 patient was asymptomatic (9%) with a confirmed diagnosis of COVID-19 by anti-S serology. Of the 283 patients, 85% were under bDMARDs, mainly on rituximab (RTX) (n=44) and infliximab (IFX) (n=136). The seroprevalence of SARS-CoV-2 in patients with rheumatic diseases, mainly under bDMARDs treatments, was 2.83%. Among infected patients, 9% were asymptomatic. Detecting SARS-CoV-2 infections could be based on the strategy using patients' interview and anti-N serology.
Identifiants
pubmed: 34883243
pii: S1297-319X(21)00185-8
doi: 10.1016/j.jbspin.2021.105312
pmc: PMC8647388
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105312Informations de copyright
Copyright © 2021 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
Références
Mult Scler Relat Disord. 2020 Sep;44:102323
pubmed: 32593961
Joint Bone Spine. 2012 Jul;79(4):365-9
pubmed: 22285615
Eur J Case Rep Intern Med. 2020 Sep 24;7(10):001922
pubmed: 33083371
Joint Bone Spine. 2021 Jan;88(1):105095
pubmed: 33152484
Lancet Rheumatol. 2020 Oct;2(10):e583-e585
pubmed: 33106791
Rheumatol Int. 2020 Dec;40(12):2015-2021
pubmed: 32945944
Mult Scler Relat Disord. 2020 Sep;44:102341
pubmed: 32622338
Radiology. 2020 Aug;296(2):E15-E25
pubmed: 32083985
Lancet. 2015 Jul 18;386(9990):258-65
pubmed: 25975452
Joint Bone Spine. 2010 Mar;77(2):142-5
pubmed: 20171921
Ann Rheum Dis. 2021 Mar 10;:
pubmed: 33692021
Ann Rheum Dis. 2021 Jun;80(6):817-819
pubmed: 33436385
Lancet Rheumatol. 2021 Jun;3(6):e419-e426
pubmed: 33786454
Nat Med. 2020 Aug;26(8):1200-1204
pubmed: 32555424
Ann Rheum Dis. 2020 Jul;79(7):859-866
pubmed: 32471903
Ann Rheum Dis. 2020 Jul 6;:
pubmed: 32632035
RMD Open. 2019 Sep 9;5(2):e001035
pubmed: 31565247
Nat Commun. 2020 Jul 24;11(1):3774
pubmed: 32709909
Joint Bone Spine. 2020 Oct;87(5):439-443
pubmed: 32445935
Ann Rheum Dis. 2021 Mar 10;:
pubmed: 33692020