Results of concurrent radiotherapy and immunotherapy in recurrent and metastatic head and neck cancer: A single-center experience.

Head and Neck Neoplasms / radiotherapy Humans Immunotherapy Neoplasm Recurrence, Local / radiotherapy Radiosurgery / methods Retrospective Studies
Head and neck cancer Immunotherapy Nivolumab Radiotherapy Re-irradiation SBRT

Journal

Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118

Informations de publication

Date de publication:
01 2022
Historique:
received: 17 11 2021
revised: 24 11 2021
accepted: 27 11 2021
pubmed: 10 12 2021
medline: 12 4 2022
entrez: 9 12 2021
Statut: ppublish

Résumé

In metastatic and recurrent head and neck cancer (M/R HN-SCC), the median survival is less than a year and locoregional recurrence is the main cause of death. Our aim was to evaluate the results of concurrent stereotactic body radiotherapy (SBRT) and immunotherapy (ICI) in these patients. Fifteen patients diagnosed with M/R HN-SCC were evaluated retrospectively. All patients received SBRT (3x8 Gy) to all recurrent and metastatic foci with concurrent ICI. Six months overall survival (OS) rates and progression-free survival (PFS) rates were 93% and 86%, respectively. Local control (LC) rate in the site of SBRT was 96%. Higher survival and LC rates were achieved with lower doses of radiotherapy with the synergistic effect of SBRT and ICI. Concurrent ICI and SBRT was feasible with excellent LC.

Identifiants

DOI: 10.1016/j.oraloncology.2021.105658 PMID: 34883400
pubmed: 34883400
pii: S1368-8375(21)00765-X
doi: 10.1016/j.oraloncology.2021.105658
pii:
doi:

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

105658

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Sezin Yuce Sari (SY)

Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: sezin_yuce@hotmail.com.

Melek Tugce Yilmaz (MT)

Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: mlktgcylmz@gmail.com.

Burak Yasin Aktas (BY)

Department of Medical Oncology, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey. Electronic address: byaktas@hacettepe.edu.tr.

Sercan Aksoy (S)

Department of Medical Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: saksoy@hacettepe.edu.tr.

Ibrahim Gullu (I)

Department of Medical Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: ibrahimhalil.gullu@hacettepe.edu.tr.

Mustafa Cengiz (M)

Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: mcengiz@hacettepe.edu.tr.

Gokhan Ozyigit (G)

Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: gozyigit@hacettepe.edu.tr.

Gozde Yazici (G)

Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Electronic address: yazicig@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Results of concurrent radiotherapy and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Results of concurrent radiotherapy and...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Results of concurrent radiotherapy and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Results of concurrent radiotherapy and...
questionsmedicales.fr › Techniques d'investigation › Techniques stéréotaxiques › Radiochirurgie › Results of concurrent radiotherapy and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Results of concurrent radiotherapy and...