SB203580-A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma.
Adult
Asthma
/ drug therapy
Bronchi
/ drug effects
Cell Differentiation
Cells, Cultured
Enzyme Inhibitors
/ pharmacology
Female
Fibroblasts
/ drug effects
Humans
Imidazoles
/ pharmacology
Male
Middle Aged
Pyridines
/ pharmacology
Signal Transduction
p38 Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
MAPK
TGF-β1
asthma
fibroblast-to-myofibroblast transition
myofibroblasts
p38
subepithelial fibrosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Nov 2021
26 Nov 2021
Historique:
received:
31
10
2021
revised:
21
11
2021
accepted:
23
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Subepithelial fibrosis is a component of the remodeling observed in the bronchial wall of patients diagnosed with asthma. In this process, human bronchial fibroblasts (HBFs) drive the fibroblast-to-myofibroblast transition (FMT) in response to transforming growth factor-β
Identifiants
pubmed: 34884593
pii: ijms222312790
doi: 10.3390/ijms222312790
pmc: PMC8657816
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Imidazoles
0
Pyridines
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
SB 203580
OU13V1EYWQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : 2019/03/X/NZ3/01801
Organisme : National Science Center
ID : 2016/23/D/NZ3/01310
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