The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.
IL-33
ST2
psoriasis
skin
vitamin D
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Nov 2021
29 Nov 2021
Historique:
received:
08
09
2021
revised:
24
11
2021
accepted:
24
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Interleukin 33 (IL-33) belongs to the IL-1 family and is produced constitutively by epithelial and endothelial cells of various organs, such as the skin. It takes part in the maintenance of tissue homeostasis, repair, and immune response, including activation of Th2 lymphocytes. Its involvement in pathogenesis of several inflammatory diseases including psoriasis was also suggested, but this is not fully understood. The aim of the study was to investigate expression of IL-33 and its receptor, ST2, in psoriasis, and the effects of the active form of vitamin D (1,25(OH)
Identifiants
pubmed: 34884710
pii: ijms222312907
doi: 10.3390/ijms222312907
pmc: PMC8657669
pii:
doi:
Substances chimiques
IL1RL1 protein, human
0
IL33 protein, human
0
Interleukin-1 Receptor-Like 1 Protein
0
Interleukin-33
0
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2017/25/B/NZ3/00431
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